在棕植物性 pustulosis 病例系列中,upadacitinib 的有效性突出了复杂的免疫反应模式
Shao-Zhen Mai1, Ru-Zeng Xue2, Xiao-Yan Wu3
1Department of Dermatology, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
概括
乌帕达西尼布有效治疗棕植物 pustulosis (PPP),在几周内改善皮肤病变. 这种治疗可能通过向与PPP有关的复杂的Th1,Th2和Th17炎症途径来起作用.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 棕植物 pustulosis (PPP) 是一种慢性,难以治疗的炎症性皮肤疾病.
- 没有完全了解PPP的确切原因.
- 了解相关的免疫通路对于开发有效治疗方法至关重要.
研究的目的:
- 为了评估upadacitinib在治疗棕植物性 pustulosis (PPP) 的疗效和安全性.
- 研究T助手 (Th) 1,Th2和Th17细胞及其相关细胞因子在PPP病变发生过程中的作用.
- 为了比较PPP患者的免疫细胞概况与慢性湿疹,牛皮和健康对照患者的免疫细胞概况.
主要方法:
- 一项临床研究监测了10名PPP患者,这些患者接受了乌帕达西提尼布治疗,以检查疗效和安全性.
- 免疫光和免疫组织化学被用来分析皮肤病变中的免疫细胞和细胞因子表达.
- 患者组包括16名PPP患者,10名慢性湿疹 (CE) 患者,10名牛皮病患者和7名健康对照患者.
主要成果:
- 乌帕达西尼布治疗导致了快速改善,在某些患者的第8周和所有患者的第52周,PPPASI90 (PPPASI得分的90%改善) 实现.
- 在PPP中,Th1细胞和IFN-γ水平升高,类似于CE和PV,并且高于HC.
- 在PPP中,Th2细胞,IL-4和IL-13水平高于HC和PV,类似于CE.
- Th17细胞,IL-17和IL-36γ水平与PV相当,高于HC和CE,表明PPP具有复杂的炎症特征.
结论:
- 乌帕达西替尼 (Upadacitinib) 作为棕植物 pustulosis (PPP) 的治疗选择,显示出显著的安全性和有效性.
- 乌帕达西提尼布的治疗效果可能源于其调节PPP特有的混合Th1,Th2和Th17免疫反应的能力.
相关概念视频
06:32Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
11.0K
We herein detail the methodology followed to compare protective efficacy and lung immune response induced by intranasal and subcutaneous immunization with BCG in mouse model. Our results show the benefits of pulmonary vaccination and suggest a role for IL17-mediated response in vaccine-induced...
11.0K
01:36Humoral Immune Responses
83.4K
Overview
83.4K
08:52Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
11.2K
Here we present an elegant protocol for in vivo evaluation of vaccine effectiveness and host immune responses. This protocol can be adapted for vaccine models that study viral, bacterial, or parasitic...
11.2K
01:11Types of Responses of Series RLC Circuits
1.7K
A second-order differential equation characterizes a source-free series RLC circuit, marking its distinct mathematical representation. The complete solution of this equation is a blend of two unique solutions, each linked to the circuit's roots expressed in terms of the damping factor and resonant frequency.
1.7K
01:22Dose-Response Relationship: Potency and Efficacy
6.4K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.4K
12:47Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
12.1K
In this protocol, we describe methods to efficiently transfect murine macrophage cell lines with siRNAs using the Amaxa Nucleofector 96-well Shuttle System, stimulate the macrophages with lipopolysaccharide, and monitor the effects on inflammatory cytokine...
12.1K