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白质的纵向变化 自闭症谱系障碍的微观结构性质:一种规范模型分析
Yi-Ling Chien1, Wan-Ling Tseng2, Chang-Le Chen3,4
1Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
自闭症谱系障碍 (ASD) 显示出持续的白质变化,特别是在状纤维. 纵向分析揭示了大脑通道的发育变化,与自闭症严重程度有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 医疗成像医学成像
背景情况:
- 自闭症谱系障碍 (ASD) 与非典型的白质发育有关.
- 以前的研究主要是横截面的,限制了对ASD随时间变化的白质变化的理解.
研究的目的:
- 研究ASD患者白质微观结构的纵向变化.
- 检查这些发育白质变化的临床相关性.
主要方法:
- 纵向扩散光谱成像 (DSI) 在75名自闭症患者中超过4.7年.
- 与680个典型发育的个体相比,使用z-score进行分数异构 (FA),轴向扩散 (AD),辐射扩散 (RD) 和平均扩散 (MD) 的规范建模.
- 对76个白质道的分析和与临床自闭症严重程度的相关性.
主要成果:
- 自闭症患者在两个时间点连接极,海马体和杏仁体的状纤维中表现出更高的AD,RD和MD.
- 几条通道随着时间的推移显示了FAz分数的增加,这表明与常态的偏差更大.
- 在特定路径中扩散度变化的增加率与基线自闭症严重程度和社会缺陷相关.
结论:
- 这些发现支持状纤维的持续变化以及ASD其他通道的发育变化.
- 该研究强调了规范建模在ASD中用于纵向白质分析的实用性.
- 白质变化与自闭症谱系障碍的临床特征有关.
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