Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

How Children Solve Problems Using Causal Reasoning06:23

How Children Solve Problems Using Causal Reasoning

14.3K
Source: Laboratories of Judith Danovitch and Nicholaus Noles—University of Louisville
Imagine a young child hears an adult say, “I want to watch the news,” then watches the adult press a button on the remote control. A moment later, the television screen turns on. The next day, the child wants to turn on the television screen to watch cartoons. How does the child know what to do? Is it enough to say, “I want to watch cartoons,” or is pushing the button on the...
14.3K
Causality in Epidemiology01:21

Causality in Epidemiology

1.5K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.5K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

8.4K
Based on resting-state functional magnetic resonance imaging with Granger causality analysis, we investigated the alterations in the directed functional connectivity between the posterior cingulate cortex and whole brain in patients with Alzheimer's Disease (AD), patients with Mild Cognitive Impairment (MCI), and healthy...
8.4K
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

1.2K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.2K
Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

1.0K
The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
1.0K
Computational Analysis Tutorial for Chimeric Small Noncoding RNA: Target RNA Sequencing Libraries07:35

Computational Analysis Tutorial for Chimeric Small Noncoding RNA: Target RNA Sequencing Libraries

1.1K
Here, we present a protocol demonstrating the installation and use of a bioinformatics pipeline to analyze chimeric RNA sequencing data used in the study of in vivo RNA:RNA...
1.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Impact of Event-Related Treatment Modifications in Exposure-Response Analyses of Repeated Time-to-Event Data.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Causal Directed Acyclic Graphs to Mitigate Confounding Bias in Exposure-Response Analyses.

CPT: pharmacometrics & systems pharmacology·2026
Same author

From In Vitro Efficacy to Long-Term HbA1c Response for GLP-1R/GlucagonR Agonism Using the 4GI-HbA1c Systems Model.

CPT: pharmacometrics & systems pharmacology·2025
Same author

The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?

The AAPS journal·2025
Same author

Tutorial on Conditional Simulations With a Tumor Size-Overall Survival Model to Support Oncology Drug Development.

CPT: pharmacometrics & systems pharmacology·2025
Same author

Development of a Joint Tumor Size-Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision-Making.

CPT: pharmacometrics & systems pharmacology·2025
Same journal

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Integrated Population Pharmacokinetic Analysis of Intravitreal Aflibercept Drug Products.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Development and Use of a Population Pharmacokinetic Model for Characterizing the Pharmacokinetics of Vonoprazan in Pediatric Patients.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

A Narrative Review of Artificial Intelligence for Drug Repurposing: Lessons From COVID-19 and Oncology (2020-2025).

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Butorphanol Pharmacokinetics Across Species: Meta-Analysis Integrating Allometric Scaling and Minimal Physiologically Based Pharmacokinetic Modeling.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework.

CPT: pharmacometrics & systems pharmacology·2026
查看所有相关文章

相关实验视频

Updated: Jan 20, 2026

How Children Solve Problems Using Causal Reasoning
06:23

How Children Solve Problems Using Causal Reasoning

Published on: April 30, 2023

14.3K

为药学学家提供因果调解分析教程.

Sebastiaan Camiel Goulooze1, Eleonora Marostica1, Nelleke Snelder1

  • 1LAP&P Consultants BV, Leiden, the Netherlands.

CPT: pharmacometrics & systems pharmacology
|January 19, 2026
PubMed
概括
此摘要是机器生成的。

因果调解分析量化了生物标志物对治疗效果的贡献,为药学家提供了一个强大的工具. 本教程介绍了使用模拟工作流程开发生物标志物的因果调解分析.

关键词:
生物标志物的发展发展.有关因果推理的推理.因果调解分析因果调解分析调解分析 调解分析药物动力学药物动力学建模

更多相关视频

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.4K
Causality in Epidemiology
01:21

Causality in Epidemiology

1.5K

相关实验视频

Last Updated: Jan 20, 2026

How Children Solve Problems Using Causal Reasoning
06:23

How Children Solve Problems Using Causal Reasoning

Published on: April 30, 2023

14.3K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.4K
Causality in Epidemiology
01:21

Causality in Epidemiology

1.5K

科学领域:

  • 制药指标 (Pharmacometrics) 是一个指标.
  • 生物标志物开发 生物标志物开发
  • 因果推理因果推理

背景情况:

  • 调解分析通过生物标志物量化治疗对临床结果的间接影响.
  • 药理学家经常使用药理动力学-药理动力学 (PK-PD) 模型分析生物标志物数据.
  • 整合调解分析增强了用于生物标志物驱动药物开发的药物计量工具包.

研究的目的:

  • 在药量学背景下引入因果调解分析概念.
  • 证明因果调解分析对生物标志物发展的应用.
  • 为实践实施提供基于模拟的工作流程,提供示例代码和数据集.

主要方法:

  • 探讨概括的因果调解分析原则.
  • 用因果调解分析应用于药量测量模型.
  • 使用基于模拟的工作流程进行分析和说明.

主要成果:

  • 展示介导分析如何量化生物标志物介导的治疗效果.
  • 说明因果调解分析对复杂的药量模型 (非线性,相互作用) 的适用性.
  • 为应用这些方法提供可重复的工作流程.

结论:

  • 因果调解分析是药理测量工具箱的一个有价值的补充.
  • 这种方法通过阐明间接治疗效应来支持生物标志物开发.
  • 该教程有助于在药量测量研究中采用因果调解分析.