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素稳定纳米颗粒的合成,表征和抗活动

Deepak Anand¹, Suriya Palamae¹, Jirakrit Saetang¹

¹International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Thailand.

Journal of food science

|January 19, 2026

概括

基托桑稳定的纳米粒子 (C-SeNPs) 有效地对抗海鲜中的多抗药性李斯特菌单细胞菌 (LM). 这些纳米颗粒显示出强大的抗菌作用和低细胞毒性,为食品保存提供了有希望的解决方案.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
食品科学食品科学食品科学

背景情况:

李斯特菌 (Listeria monocytogenes,简称LM) 是一种重要的食源性病原体,对公众健康构成风险.
开发用于食品保存的有效抗菌剂对于防止LM污染至关重要.
纳米颗粒 (SeNPs) 已经显示出抗菌性质,但它们的稳定性和有效性可以通过稳定性来提高.

研究的目的:

为了合成和表征素稳定纳米粒子 (C-SeNPs).
评估C-SeNPs对抗多药耐药的Listeria monocytogenes的抗菌疗效.
评估C-SeNPs作为食品防腐剂的潜力,特别是在海鲜中.

主要方法:

通过基托稳定C-SeNPs的合成.
使用TEM,SEM,DLS,泽塔电位分析,XRD,ICP-OES,EDX,UV-Vis和光光谱等技术对C-SeNP进行表征.
通过MIC,MBC和杀时动力学测试来确定抗菌活性.
评估C-SeNPs在注射中的疗效,并评估细胞毒性.

主要成果:

C-SeNPs表现出球形形态,平均水力动力直径为173.4nm,并且具有良好的体稳定性.
基本 (Se0) 含量被确定为29.80 ± 0.35 mg/L.
C-SeNPs对MIC和MBC值分别为130和260μg/ml的多药耐药LM表现出强大的抗菌活性.
在2×MIC下,在24小时内实现了完全的细菌失活,有细菌膜破坏的证据.
在抑制的LM生长方面,C-SeNP比酸更有效,并且显示出较低的细胞毒性.

结论:

C-SeNPs具有显著的抗菌功效,可以对抗多药耐药的Listeria monocytogenes.
具有特征的C-SeNPs的物理化学特性支持它们作为有效的抗菌剂的潜力.
作为海鲜的安全有效的天然防腐剂,C-SeNPs显示出承诺,为传统方法提供了替代方案.

关键词:

抗微生物药物抗微生物药物李斯特里亚单细胞原生菌 (Listeria monocytogenes) 是一种食物传播的病原体离子泄漏是因为离子泄漏.纳米颗粒是一种纳米颗粒.

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