Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain03:26

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

3.5K
The protocol outlines the surgical procedure for the treatment of postamputation pain using Targeted Muscle Reinnervation (TMR). TMR will be compared with two other surgical techniques, specifically Regenerative Peripheral Nerve Interface (RPNI) and neuroma excision, followed by immediate burying within muscle under the context of an international, randomized controlled...
3.5K
Censoring Survival Data01:09

Censoring Survival Data

529
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
529
The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials08:36

The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

1.1K
Here, we present a protocol to analyze the effectiveness and safety of Angong Niuhuang Pill in the treatment of viral...
1.1K
The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

1.1K
This protocol aims to investigate the neural activity related to social comparison and social distance during the processing of intertemporal decision outcomes. Indifference points will be measured using event-related potentials as part of the...
1.1K
Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain03:53

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

2.9K
Here, we describe the surgical procedure to perform Regenerative Peripheral Nerve Interface (RPNI) surgery for treating postamputation neuropathic pain in the context of an international, randomized controlled trial (RCT) (ClinicalTrials.gov, NCT05009394). The RCT compares RPNI with two other surgical techniques, namely, Targeted Muscle Reinnervation (TMR) and neuroma excision combined with intra-muscular...
2.9K
Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons07:59

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

1.9K
One challenge of analyzing synchronized time-series experiments is that the experiments often differ in the length of recovery from synchrony and the cell-cycle period. Thus, the measurements from different experiments cannot be analyzed in aggregate or readily compared. Here, we describe a method for aligning experiments to allow for phase-specific...
1.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Safety of immune checkpoint inhibitors in a diverse patient population: a single-institution experience.

Ecancermedicalscience·2026
Same author

Buprenorphine-Naloxone vs Extended-Release Naltrexone Following Opioid Withdrawal Treatment.

JAMA network open·2026
Same author

Methodological innovations to advance substance use disorder research: Proceedings of a NIDA workshop on target trial emulation and translational testing of digital health tools.

Journal of substance use and addiction treatment·2026
Same author

Mindfulness-Based Group Medical Visits for Persons With Chronic Low Back Pain: A Randomized Clinical Trial.

JAMA internal medicine·2026
Same author

Impacts of personal or family COVID-19 infection on health-related quality of life among patients with opioid use disorder.

Journal of substance use·2026
Same author

COVID-19 pandemic-related stress and substance use behaviors among people with HIV - a mixed method analysis.

PloS one·2026

相关实验视频

Updated: Jan 20, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K

使用伪观测对随机对照试验设置中的时间到事件审查数据进行通用对对比比较.

Stephanie Pan1, Prasad Patil1, Janice Weinberg1

  • 1Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Statistical methods in medical research
|January 19, 2026
PubMed
概括

使用伪观测的新方法改善了临床试验中对受审查的时间到事件数据的通用对对比 (GPC). 它减少了偏差和错误,特别是在不平等的学中,增强了治疗效果分析.

关键词:
一般化的对对比比较.被审查的数据是被审查的数据.临床试验是指临床试验中的临床试验.伪观测是一种假观测.生存分析,生存分析.赢得比率比率的胜利比率.

更多相关视频

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.1K
The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

1.1K

相关实验视频

Last Updated: Jan 20, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.1K
The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

1.1K

科学领域:

  • 生物统计学 生物统计学
  • 临床试验方法论 临床试验方法论
  • 生存分析的分析.

背景情况:

  • 通用对对比 (GPC) 方法扩展了曼-惠特尼在随机对照试验 (RCT) 中对优先结果排名的方法.
  • GPC方法可以分析受审查的时间到事件数据,但由于审查,偏差可能来自不确定的对.
  • 胜利比率 (WR) 是一种GPC测量,可以解释为逆危险比率,但对审查敏感.

研究的目的:

  • 提出一种新的GPC方法,使用伪观察来解决因时间到事件结果中的审查引起的无信息对.
  • 通过模拟在各种审查场景下对现有GPC方法进行对比,评估拟议方法的性能.

主要方法:

  • 开发一种新的GPC方法,利用伪观测来处理受审查的数据.
  • 比较模拟研究,评估在各种审查比例和分布下 (平等与不平等的学) 的表现.
  • 对偏差的评估,根的平均平方误差,以及与已建立的GPC方法 (Gehan和Latta) 相比的统计能力.

主要成果:

  • 拟议的方法显示了与现有的GPC方法在相同的学和行政审查条件下可比的性能.
  • 对于不平等的学,绩效取决于审查比例和分布,新方法减少偏差和RMSE.
  • 尽管减少了偏差和错误,但在拟议的方法中没有观察到统计能力的改善.

结论:

  • 新的伪观测GPC方法有效地减轻了与对时间到事件数据的审查相关的偏见和错误,特别是在失业率不平等的场景中.
  • 虽然这种方法不会增加统计能力,但它为分析有审查结果的RCT数据提供了有价值的替代方案.
  • 该方法通过使用重建的随机对照试验数据集成功说明了这一方法.