在大动脉缩中进行手术前动脉瘤扩张:一个罕见的病例报告

This novel model creates robust infrarenal abdominal aortic aneurysms in swine using a combination of balloon angioplasty, elastase/collagenase perfusion, topical elastase application, and oral compound β-aminopropionitrile administration, which interferes with collagen...

This video shows how to induce abdominal aortic aneurysms (AAA) in mice via transient intraluminal infusion of porcine pancreatic elastase into the infrarenal segment of the abdominal aorta. The model has the ability to add broad insight into the pathobiology of AAA due to the emergence of numerous transgenic and gene knockout...

Source: Hannah L. Cebull1, Arvin H. Soepriatna1, John J. Boyle2 and Craig J. Goergen1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana
2Mechanical Engineering & Materials Science, Washington University in St. Louis, St Louis, Missouri
The mechanical behavior of soft tissues, such as blood vessels, skin, tendons, and other organs, are strongly influenced by their composition of elastin and collagen, which provide elasticity and strength. The fiber...

Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion...

This protocol describes a calcium phosphate-induced abdominal aortic aneurysm (AAA) mouse model to study the pathological features and molecular mechanisms of...

This study describes a modified octopus technique for endovascular treatment of thoracoabdominal aortic aneurysms, demonstrating favorable clinical...