相关实验视频

Updated: Jan 20, 2026

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Published on: September 13, 2016

生物启发的生物材料工程重建了中风后神经再生的Stromal-Parenchymal相互作用

Bingyu Li¹, Shuguang Li¹, Jingge Zhang¹

¹School of Pharmaceutical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, State Key Laboratory of Antiviral Drugs, Tianjian Laboratory of Advanced Biomedical Sciences, Pingyuan Laboratory, Zhengzhou University, Zhengzhou, Henan, China.

Advanced materials (Deerfield Beach, Fla.)

|January 19, 2026

概括

这项研究开发了一种工程生物材料,用于在中风后再生大脑组织. 该材料通过模仿细胞外基质和调节炎症来促进神经再生和功能恢复.

科学领域:

生物材料科学生物材料科学
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

脑卒中会导致严重的神经障碍,原因是大脑组织再生受损.
炎症和缺乏细胞外基质 (ECM) 阻碍了中风腔中的内生修复.

研究的目的:

开发一种工程生物材料,在中风腔内重新创造一个再生.
促进脑组织再生和缺血性中风后的功能恢复.

主要方法:

整合了一个DNA水凝与工程介质干细胞 (eMSCs) 和神经干细胞 (NSCs).
水凝模仿了本地ECM特性,以支持细胞活力和保留.
eMSCs调节炎症,抑制质痕,并促进血管再生.

主要成果:

在大鼠中风模型中,工程生物材料显著促进了神经元再生和突触重塑.
观察到增强的新血管化和改善的运动和认知功能.
该系统成功地重新创建了树皮-体相互作用,以促进修复.

结论:

这种模块化策略为中风后大脑再生提供了一个有前途的治疗方法.
重新建立肌-肌相互作用是修复受损神经组织的关键.
工程生物材料可以克服中风后内源性修复的障碍.

关键词:

这是一种DNA水凝.调节炎症调节炎症缺血性中风中风神经的再生神经的再生干细胞是干细胞的组成部分.

更多相关视频

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

相关概念视频

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial...

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

This protocol describes a novel three-dimensional in vitro model, where corneal stromal cells and differentiated neuronal cells are cultured together to assist in the examination and understanding of the interactions of the two cell...

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Esophageal reconstruction is a challenging procedure, and development of a tissue-engineered esophagus that enables regeneration of esophageal mucosa and muscle and that can be implanted as an artificial graft is necessary. Here, we present our protocol to generate an artificial esophagus, including scaffold manufacturing, bioreactor cultivation, and various surgical...

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

This paper presents a series of protocols for developing engineered cells and functionalized surfaces that enable synthetically engineered E. coli to control and manipulate programmable material...

Preparation of Functional Silica Using a Bioinspired Method

Preparation of Functional Silica Using a Bioinspired Method

Here, we present a protocol to synthesize bioinspired silica materials and immobilize enzymes therein. Silica is synthesized by combining sodium silicate and an amine 'additive', which neutralize at a controlled rate. Material properties and function can be altered either by in situ enzyme immobilization or post-synthetic acid elution of encapsulated...

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

This manuscript details the fabrication of micro-tissue engineered neural networks: three-dimensional micron-sized constructs comprised of long aligned axonal tracts spanning aggregated neuronal population(s) encased in a tubular hydrogel. These living scaffolds can serve as functional relays to reconstruct or modulate neural circuitry or as biofidelic test-beds mimicking gray-white matter...