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Updated: Jan 20, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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一种由瘤酸性激活的电荷逆转前药物,用于选择性癌症化疗

Bing Liu1, Guanchun Wang2, Quanjun Yang3

  • 1The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China. hp158@sjtu.edu.cn.

Biomaterials science
|January 19, 2026
PubMed
概括

一种新的电荷逆转前药物PIX-DMMA显示出对癌症治疗的前景. 它是由瘤微环境激活的.

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In this video, we demonstrate an alkaline single-cell electrophoresis assay to quantify both single- and double-strand DNA breaks in doxorubicin-treated cells. Alkaline conditions disrupt the hydrogen bonds between DNA base pairs, resulting in the complete unwinding and separation of DNA strands. This allows differential migration of undamaged and damaged DNA fragments in agarose gel upon electrophoresis, revealing a comet-shaped structure of slowly migrating undamaged DNA forming the circular...
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