OptoLoop:,

Martin Stortz1, Adib Keikhosravi2, Gianluca Pegoraro2

  • 1Cell Biology of Genomes, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Journal of cell science
|January 19, 2026
PubMed
概括

科学家们开发了OptoLoop,一个光激活系统,以精确控制基因组组织. 这种工具揭示了DNA循环可以抑制人类端粒酶基因 (TERT) 表达.

相关概念视频

Optogenetic Functional MRI06:06

Optogenetic Functional MRI

This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living...
15.4K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Here, we present a protocol to access and analyze many human and model organism databases efficiently. This protocol demonstrates the use of MARRVEL to analyze candidate disease-causing variants identified from next-generation sequencing...
10.3K
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.7K
Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

A mass spectrometry-guided genome mining protocol is established and described here. It is based on genome sequence information and LC-MS/MS analysis and aims to facilitate identification of molecules from complex microbial and plant...
11.6K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

This protocol provides a workflow on how to combine artificial microRNA-mediated RNA interference with optogenetics to stimulate specifically presynaptic boutons with reduced expression of selective gene(s) within intact neuronal...
10.6K
Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Here, we present a protocol introducing a set of new ex-ovo experiments and physical modeling approaches for studying the mechanics of morphogenesis during early chick embryonic brain...
7.7K