使用多项式混沌扩张对头癌高温症治疗计划的不确定性分析
Roel C Kwakernaak1, Massimiliano Zanoli1, Zoltán Perkó2
1Radiotherapy, Erasmus MC, P.O. Box 2040, Rotterdam, 3000 CA, NETHERLANDS.
Physics in medicine and biology
|January 19, 2026
概括
准确的患者定位和组织属性测量对于有效的头癌高温治疗至关重要. 不确定性显著影响温度分布,影响处理质量.
科学领域:
- 在瘤学瘤学.
- 医学物理 医学物理
- 生物医学工程 生物医学工程
背景情况:
- 过热 (瘤温度升高) 是治疗头癌的有效辅助剂,增强了放射治疗和化疗.
- HyperCollar3D应用器用于H&N癌症高温症治疗计划 (HTP).
研究的目的:
- 使用HyperCollar3D应用器研究HTP对H&N癌症的强度.
- 评估患者定位的不确定性,组织特性和水栓冷却对HTP的影响.
主要方法:
- 在伊拉斯医疗中心治疗的16名H&N癌症患者的回顾性分析.
- 利用多项式混沌扩展来模拟不确定性对温度分布和治疗质量指标的影响.
主要成果:
- 组织特性中的不确定性导致了显著的温度变化 (2.1°C T90 95% CI).
- 患者定位错误 (5mm) 进一步加剧了变化 (2.3°C T90 95% CI).
- 介电组织属性不确定性 (47%) 和定位错误 (22%) 是T90变异的主要原因.
结论:
- 精确的组织特性测量和精确的患者定位对于有效的H&N癌症高温至关重要.
- 开发强大的,定量化的HTP和输送方法对于提高精度和临床疗效至关重要.
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