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动脉样硬化中的肠道微生物群衍生小分子:生物合成,机械洞察力和转化潜力

Ruolan Sun^1,2,3, Youzhe Chen², Xiaoyu Tang^1,2

¹Shenzhen Medical Academy of Research and Translation (SMART), Shenzhen 518107, China.

Journal of natural products

|January 19, 2026

概括

肠道微生物产生影响动脉样硬化 (AS) 的小分子,这是心血管疾病的关键驱动因素. 了解这些分子为AS预防和治疗提供了新的途径.

科学领域:

微生物学微生物学
心血管科学心血管科学
代谢学代谢学代谢学

背景情况:

动脉样硬化 (AS) 是全球心血管疾病死亡的主要原因.
肠道微生物群衍生小分子 (GMDSMs) 越来越多地被认为是AS病变的关键调节者.
转基因生物多样性药物会影响脂质代谢,血管炎症和血栓形成.

研究的目的:

审查与AS有机关关联的代表性GMDSM.
突出这些分子的生物合成途径,微生物来源和宿主目标.
讨论针对AS预防微生物代谢的治疗策略.

主要方法:

关于GMDSM和AS的机械学研究的文献综述.
GMDSM的分类包括氨基酸衍生物,脂肪酸,三甲基胺N-氧化物,胆酸和细菌膜部分.
对微生物酶,种群和宿主点的分析,这些点都涉及到有氧原体或保护作用.

主要成果:

确定了特定的GMDSM (例如,TMAO,胆酸) 在AS中具有既定的作用.
详细介绍了不同的微生物宿主代谢途径,将饮食,微生物群和心血管结果联系起来.
强调了GMDSM在促进或保护AS方面的双重作用.

结论:

在AS发展过程中,GMDSM是关键的调解者.
基于微生物组的干预措施对预防心血管疾病充满希望.
对GMDSM多样性和功能的进一步研究将推动基于微生物组的AS诊断和治疗.

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