生命的基本8和心血管健康:对慢性呼吸道疾病的保护作用
Jianli Ma1, Xiyu Cao1, Zhipeng Ma1
1Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
概括
使用生命必需8 (LE8) 指标保持最佳心血管健康 (CVH) 与慢性呼吸道疾病 (CRD) 的风险降低有关. 高CVH也与较低的全因死亡率和慢性下呼吸道疾病有关.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 慢性呼吸道疾病 (CRDs) 构成了全球重大健康负担.
- 个人生活方式因素对CRD的影响已知,但全面心血管健康 (CVH) 指标,如Life's Essential 8 (LE8) 对CRD和死亡率的影响不太清楚.
- 关于LE8和CRD风险和死亡率之间的关联,人口层面的数据有限.
研究的目的:
- 为了研究生命的基本8 (LE8) 评分和慢性呼吸系统疾病 (CRDs) 的风险在美国大人口之间的关联.
- 检查LE8与所有原因和慢性下呼吸道疾病 (CLRD) 的死亡率之间的关系.
主要方法:
- 一项观察性研究利用了来自美国国家健康和营养检查调查 (NHANES 2007-2018) 的数据,其中包括30863名参与者.
- 使用调查加权后勤回归和考克斯模型来评估LE8和CRD风险和死亡率之间的关联,并对混因素进行调整.
- 限制立方线 (RCS) 用于评估非线性关系,并补充了子组和灵敏度分析.
主要成果:
- 在LE8得分和CRD及其亚型的风险之间发现了显著的反向关联,肺气显示出最强的联系 (OR=0.96).
- RCS分析表明,LE8和CRD风险之间存在非线性关系.
- 与低CVH患者相比,高CVH (高LE8得分) 个体的全因死亡率 (HR=0.82) 和CLRD死亡率 (HR=0.27) 的风险明显较低.
结论:
- 生活必需品8 (LE8) 与慢性呼吸道疾病 (CRD) 的风险相反相关.
- 通过LE8指标实现最佳心血管健康 (CVH) 提供了对所有原因和慢性下呼吸道疾病 (CLRD) 死亡率的保护.
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