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Updated: Jan 20, 2026

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
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用分子粘剂准活性RAS

Wenjing Su1, Xuben Hou2

  • 1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

Pharmaceutical science advances
|January 19, 2026
PubMed
概括

与现有疗法相比,针对KRASG12C突变的新型三复合抑制剂显示出更高的临床前疗效. 这些进展为RAS向癌症治疗提供了有希望的范式转变,可能带来更持久的患者益处.

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