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相关概念视频

The Ras Gene02:38

The Ras Gene

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
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Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags10:10

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

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This protocol describes light-triggered nuclear translocation of guests in living cells using caged molecular glue tags. This method is promising for site-selective nuclear-targeting drug...
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To demonstrate MR cancer molecular imaging with a small peptide targeted MRI contrast agent specific to clotted plasma proteins in tumor stroma in a mouse prostate cancer...
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The genetically tractable nematode Caenorhabditis elegans can be used as a simple and inexpensive model for drug discovery. Described here is a protocol to identify anticancer therapeutics that inhibit the downstream signaling of RAS and EGFR...
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Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

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Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
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Modeling an Enzyme Active Site using Molecular Visualization Freeware14:37

Modeling an Enzyme Active Site using Molecular Visualization Freeware

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A key skill in biomolecular modeling is displaying and annotating active sites in proteins. This technique is demonstrated using four popular free programs for macromolecular visualization: iCn3D, Jmol, PyMOL, and UCSF...
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相关实验视频

Updated: Jan 20, 2026

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
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Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

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用分子粘剂准活性RAS.

Wenjing Su1, Xuben Hou2

  • 1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

Pharmaceutical science advances
|January 19, 2026
PubMed
概括

与现有疗法相比,针对KRASG12C突变的新型三复合抑制剂显示出更高的临床前疗效. 这些进展为RAS向癌症治疗提供了有希望的范式转变,可能带来更持久的患者益处.

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 药物发现 药物发现 药物发现

背景情况:

  • 激活RAS基因突变,特别是KRASG12C,在许多癌症中很常见,并且历史上很难在治疗上准.
  • 开发KRASG12C全抑制剂 (索托拉西布,阿达格拉西布) 是一个显著的进步,但响应深度和持续时间的限制需要进一步的创新.

研究的目的:

  • 探索由RAS突变驱动的癌症的新疗法策略.
  • 评估针对激活RAS变体的新型三复合抑制剂的临床前疗效.

主要方法:

  • 新型三复合抑制剂的临床前评估 (RMC-7977,RMC-6236).
  • 与Adagrasib等现有的KRASG12C抑制剂进行比较的疗效研究.

主要成果:

  • 新型三复合抑制剂显示出有希望的临床前疗效.
  • 这些新药在临床前模型中显示出与阿达格拉西布相比更高的性能.

结论:

  • 三复合抑制剂代表了针对RAS的癌症治疗的重大进展.
  • 这些发现表明RAS瘤学的潜在范式转变,提供了更好的治疗效益.
  • 需要对这些新型抑制剂进行进一步的临床研究.

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相关实验视频

Last Updated: Jan 20, 2026

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
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