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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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The fundamentals of radiation planning and delivery for proton therapy using prostate cancer as a model are presented. The application of these principles to other selected disease sites highlights how proton radiotherapy may enhance clinical outcomes for cancer...
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NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements08:54

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Here, high-resolution 1H and 13C Nuclear Magnetic Resonance (NMR) spectroscopy was used as a rapid and reliable tool for quantitative and qualitative analysis of encapsulated fish oil...
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Proton Exchange Membrane Fuel Cells09:40

Proton Exchange Membrane Fuel Cells

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Source: Laboratories of Margaret Workman and Kimberly Frye - Depaul University
The United States consumes a large amount of energy – the current rate is around 97.5 quadrillion BTUs annually. The vast majority (90%) of this energy comes from non-renewable fuel sources. This energy is used for electricity (39%), transportation (28%), industry (22%), and residential/commercial use (11%). As the world has a limited supply of these non-renewable sources, the United States (among others) is...
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Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart06:07

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Myocardial gene therapy for ischemic heart disease holds great promise for future therapeutics. Here, we introduce a large animal model for evaluating the efficacy of gene therapy in the ischemic...
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Proton (¹H) NMR: Chemical Shift01:07

Proton (¹H) NMR: Chemical Shift

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Organic molecules primarily contain carbon and hydrogen atoms. While all the hydrogen isotopes are NMR-active, protium or hydrogen-1 is the most abundant. It has a significant energy separation between its nuclear spin states due to its large gyromagnetic ratio. As per Boltzmann's distribution, an increase in the energy separation implies a greater excess population of nuclei available for excitation, resulting in a strong NMR absorption signal.
Absorption signals of all the protium nuclei...
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

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This article presents a protocol for establishing a ligature-induced model of murine periodontitis involving multiple maxillary molars, resulting in larger areas of the involved gingival tissue and bone for subsequent analysis as well as reduced animal usage. A technique to assess oral neutrophils in a manner analogous to human subjects is also...
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相关实验视频

Updated: Jan 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

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一个ESTRO-EPTN德尔菲共识关于质子治疗中的稳定性评估.

Francesco Fracchiolla1, Arturs Meijers2, Ester Orlandi3,4

  • 1UO Fisica Sanitaria, APSS, Trento, Italy.

Physics and imaging in radiation oncology
|January 19, 2026
PubMed
概括

在质子疗法规划中的稳定性评估缺乏共识. 这项ESTRO研究调查了专家,就关键的不确定性和方法达成一致,指导未来的治疗规划系统开发.

关键词:
达成共识 达成共识欧洲粒子疗法网络质子疗法是一种质子疗法.稳固性评估 稳固性评估

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NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
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Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart
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相关实验视频

Last Updated: Jan 20, 2026

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NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
08:54

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Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart
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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 临床质子疗法临床质子疗法

背景情况:

  • 稳定性评估 (RE) 对于质子疗法规划至关重要,但缺乏标准化的国际指南.
  • 目前,诊所采用各种自主开发的RE方法,专注于特定的不确定性.

研究的目的:

  • 在质子疗法中调查临床RE方法的专家意见.
  • 通过建立共识,为未来治疗计划系统 (TPS) 的开发提供信息.

主要方法:

  • 德尔菲手术涉及24个欧洲质子疗法中心 (辐射瘤学家和医学物理学家).
  • 起草和审查39份关于向强大优化规划过渡的声明.
  • 在两轮会议中,根据75%的协议门达成共识.

主要成果:

  • 在39个声明中有26个 (66.7%) 达成了共识,其中5个被确定为优先级高.
  • 在不确定性 (范围,设置,分数内,解剖学变化) 和RE的方法论上有强烈的共识.
  • 关于在规划和剂量报告中使用规划目标量 (PTV) 存在分歧.

结论:

  • 埃斯特罗·德尔菲共识为RE的协议领域提供了实际指导.
  • 建议制定指导方针,以标准化可再生能源方法和报告.
  • 鼓励TPS供应商将软件开发与社区的强有力的规划要求保持一致.