睡眠障碍在骨关节炎中的患病率和影响:系统性审查和元分析
Sylvain Mathieu1,2, Anne-Christine Rat3, Jérémie Sellam4,5
1University of Clermont Auvergne, CHU Clermont-Ferrand, Inserm, Neuro-Dol, Clermont-Ferrand, France.
Osteoarthritis and cartilage open
|January 19, 2026
概括
睡眠障碍在骨关节炎患者中很普遍,影响疼痛和残疾. 早期调查和睡眠障碍的管理对于改善患者在骨关节炎的结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 骨关节炎 (OA) 症状负担越来越多地与睡眠障碍 (SD) 相关.
- 在OA患者中SD的流行病学和临床影响需要进一步描述.
- 了解SD的流行和影响对于全面的OA管理至关重要.
研究的目的:
- 系统地审查和分析骨关节炎患者睡眠障碍的患病率.
- 评估睡眠障碍对OA患者报告结果的影响.
- 量化特定睡眠障碍的影响,如失眠,睡眠呼吸暂停和不安腿综合征 (RLS) 在OA.
主要方法:
- 系统的文献综述和研究的元分析来自PubMed,Embase,科学网络和Cochrane图书馆.
- 收集了匹兹堡睡眠质量指数 (PSQI),睡眠效率和SD (失眠,睡眠呼吸暂停,RLS) 的流行率的数据.
- 使用转比例计算了患病率,并使用逆方差或曼特尔-汉泽尔方法比较了结果.
主要成果:
- 分析了代表289,914名OA患者的81篇文章.
- 在OA患者中,SD的总体患病率为68.9%,其中睡眠呼吸暂停为32.0%,失眠为34.0%,RLS为51.6%.
- 与对照人群相比,患有SD的OA患者的睡眠质量较差 (PSQI更高),睡眠效率较低,疼痛增加,BMI更高,抑郁和灾难化率更高.
结论:
- 睡眠障碍在骨关节炎患者中非常普遍.
- SD对OA患者的疼痛,疲劳和残疾产生负面影响.
- 调查和管理睡眠障碍对于改善OA患者的整体福祉至关重要.
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