一种含有生物降解抗微生物寡合物的生物降解水凝,用于治疗耐药细菌感染的皮肤伤口

Min Wang1, Xinyun Zeng1, Xiuping Wang1

  • 1Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and Department of Chemistry, Hunan University, Changsha, 410082, China.

PubMed
概括

一种新的可生物降解的抗微生物聚合物 - - 奥利戈阿米丁 (OA1) 集成到热敏水凝中,有效地对抗皮肤感染中的多药耐药细菌. 这种创新的伤口带为挑战性感染提供了用户友好的解决方案.

相关概念视频

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

The protocol describes a step-by-step method to set up an ex vivo ovine wounded skin model infected with Staphylococcus aureus. This high-throughput model better simulates infections in vivo compared with conventional microbiology techniques and presents researchers with a physiologically relevant platform to test the efficacy of emerging...
2.4K
In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Infections caused by multidrug-resistant (MDR) bacterial strains have emerged as a serious threat to public health, necessitating the development of alternative therapeutics. We present a protocol to evaluate the effectiveness of antimicrobial blue light (aBL) therapy for MDR Acinetobacter baumannii infections in mouse burns by using bioluminescence...
9.9K
A Murine Skin Wound Infection Model to Study the Immune Response against a Bacterial Pathogen04:00

A Murine Skin Wound Infection Model to Study the Immune Response against a Bacterial Pathogen

This video demonstrates a technique to generate a murine model of skin wound infection. Upon infecting mice — engineered to express a fluorescent protein in neutrophils — with a genetically modified bioluminescent Staphylococcus aureus — a pathogenic bacteria. The bacterial burden at the infection site and the neutrophil recruitment dynamics can be studied using whole animal...
958
Demonstration of the Rat Ischemic Skin Wound Model08:35

Demonstration of the Rat Ischemic Skin Wound Model

The rat, due to its size, availability, and rather docile behavior, has been utilized as a research model for many years. The goal of this protocol is to utilize the rat as an ischemic skin wound healing model to provide valuable insight into the pathophysiology of chronic...
22.4K
Generating an Ex Vivo Ovine Wounded Skin Model Infected with a Bacterial Pathogen02:13

Generating an Ex Vivo Ovine Wounded Skin Model Infected with a Bacterial Pathogen

The video demonstrates the generation of an ex vivo ovine skin model infected with Staphylococcus aureus. This entails treating a lamb's forehead skin biopsy section with antibiotics, establishing a wound bed, positioning it on a permeable membrane in a multiwell plate with antibiotic-free medium, and establishing bacterial infection in the skin...
450
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

This article describes a step-by-step protocol to set up an ex vivo porcine model of bacterial keratitis. Pseudomonas aeruginosa is used as a prototypic organism. This innovative model mimics in vivo infection as bacterial proliferation is dependent on the ability of the bacterium to damage corneal...
6.1K