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Updated: Jan 20, 2026

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单壁碳纳米管传感器:制备和生物应用取得了进展

Xiaotong Chen¹, Difan Wang¹, Wenshuo Ding¹

¹NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Pharmaceutical science advances

|January 19, 2026

概括

单壁碳纳米管 (SWCNT) 光学生物传感器为检测小分子和生物分子提供高灵敏度. 功能化的SWCNT可以推进实时生物分析和疾病诊断.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
分析化学分析化学

背景情况:

分子识别和检测在生物分析中至关重要,面临着各种因素带来的挑战.
基于单壁碳纳米管 (SWCNT) 的光学生物传感器为生物检测提供高灵敏度,光稳定性和组织透明度.
净化和功能化SWCNT是实时监测和高通量选生物分析物的关键策略.

研究的目的:

审查单基拉SWCNTs的准备方法和功能化技术.
评估功能化的SWCNT生物传感器在识别小分子和生物分子中的应用.
突出SWCNT生物传感器在复杂生物系统和临床疾病诊断中的潜力.

主要方法:

讨论了单基拉SWCNTs的准备方法.
介绍了SWCNTs (寡核酸链,,表面活性剂修饰) 的共价和非共价功能化技术.
评估功能化的SWCNT生物传感器对小分子 (气体,神经递质,ROS) 和生物分子 (蛋白质,核酸,脂质) 的应用.

主要成果:

功能化的SWCNT生物传感器在检测挥发性有机化合物,信号分子和活性氧物种等小分子方面表现出高灵敏度和特异性.
SWCNT生物传感器有效地识别各种生物分子,包括蛋白质,核酸和脂质.
与微流体平台和机器学习的集成提高了复杂生物系统中的传感器性能.

结论:

功能化的SWCNT生物传感器为分析生物系统提供了先进的能力,并为疾病机制提供了新的见解.
SWCNT生物传感器显示出显著的潜力,可以提高临床疾病诊断的准确性和及时性,提高患者的预后.
该审查强调了SWCNT生物传感器在未来生物医学进步方面的巨大潜力.

关键词:

生物传感器是一种生物传感器.功能化的功能化.分子识别分子识别接近红外的光效应接近红外.单壁碳纳米管是一种单壁碳纳米管.

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