谷氨减少酶与绝经后骨质疏松症之间的关联:一项回顾性研究
Jili Wang1,2,3, Kaixuan Wu3, Menghan Chen3
1The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in endocrinology
|January 19, 2026
概括
在绝经后的骨质疏松症患者中,氨酸减少酶 (GR) 水平较高. 升高的GR (≥55.8U/L) 被认为是发展这种疾病的重要危险因素.
科学领域:
- 生物化学 生物化学
- 老年学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 氧化压力与绝经后骨质疏松症的发病因子有关.
- 氨酸减少酶 (GR) 是一种关键的抗氧化酶.
- 在绝经后骨质疏松症中GR的具体作用还不清楚.
研究的目的:
- 调查谷氨减少酶 (GR) 与绝经后骨质疏松症之间的关联.
- 确定GR作为绝经后骨质疏松症的潜在风险因素.
主要方法:
- 对401名绝经后妇女 (≥45岁) 的回顾性分析.
- 骨质疏松症 (OP) 和非骨质疏松症 (非OP) 组的比较,使用t测试和后勤回归.
- 通过 LASSO 回归和多变量逻辑回归进行变量选择.
- 模型性能通过ROC曲线,C指数,校准曲线和DCA进行评估.
主要成果:
- 与非OP组相比,OP组的BMI,BMD (腰椎,大腿骨,部) 较低,年龄,ADA和GR水平较高.
- 在ROC分析中,GR的AUC为0.604,临界值为55.8U/L.
- 通过后勤和LASSO回归,GR ≥55.8U/L被确定为绝经后骨质疏松症的危险因素.
结论:
- 氨酸减少酶 (GR) 与绝经后的骨质疏松症有显著的关联.
- GR水平≥55.8U/L代表了绝经后骨质疏松症的重要危险因素.
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