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Updated: Jan 20, 2026

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

Published on: October 29, 2019

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在活体中,在一个人性化的小鼠模型系统中,将原性反感寡核酸输入人类白细胞

Nathan B Seidel1, Saurav S Rout1, Beverly Z Packard2

  • 1Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

Molecular therapy. Methods & clinical development
|January 19, 2026
PubMed
概括

一种新型的输送系统在体内有效地将反意义寡核酸 (ASO) 输送到人类免疫细胞中. 这一突破使得针对HIV和其他疾病的潜在新疗法能够有针对性地提供.

关键词:
在ASO的基础上,ASO是ASO.化物质的化物人性化的小鼠.在活体中,活体中提供寡核酸的输送.

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