维生素D缺乏和多发性硬化复发:一个元分析
Yujing Zhang1, Shasha Yu1, Yu Zu1
1Department of Neurology, Bejing Fengtai You'anmen Hospital, Beijing, China.
Frontiers in neurology
|January 19, 2026
概括
维生素D补充剂在多发性硬化症 (MS) 患者中增加了25-氧维生素D水平. 低至中等剂量显著降低年复发率 (ARR),而高剂量没有显著影响.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 维生素D缺乏症在多发性硬化症患者中很常见,可能会影响疾病的活动.
- 维生素D水平与MS复发率之间的关系需要进一步澄清.
研究的目的:
- 系统地评估血清25-氧维生素D[25(OH) D]和多发性硬化症的年复发率 (ARR) 之间的剂量反应关系.
- 研究维生素D补充剂在降低多发性硬化症复发风险方面的有效性.
主要方法:
- 在2025年4月之前发表的随机对照试验 (RCT) 的元分析.
- 在包括PubMed,Medline,Web of Science,Cochrane图书馆和EMBASE在内的主要数据库中进行搜索.
- 使用Cochrane RoB-2工具评估研究质量;使用RevMan 5.3.3进行的元分析.
主要成果:
- 包括9项研究,共1078名参与者.
- 维生素D补充剂显著增加了血清25(OH) D水平 (汇总的MD=44.97).
- 低剂量/中剂量的维生素D显著降低了ARR (汇总的MD=-0.14),但高剂量的维生素D没有 (汇总的MD=0.05). 没有发现总体显著的ARR降低.
结论:
- 补充维生素D有效地增加了MS患者的血清25~OH) D水平.
- 低/中剂量维生素D可能有助于减少多发性硬化症复发,而高剂量补充没有显著的影响.
- 维生素D补充剂没有显著影响扩大残疾状况量表 (EDSS) 的得分.
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