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Updated: Jan 20, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

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抑制雌激素受体α稳定了自身免疫性肝炎中调节性T细胞功能

Lina Zhang1,2, Barbora Gromova1,3, Du Hanh Nguyen1,4

  • 1Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

JHEP reports : innovation in hepatology
|January 19, 2026
PubMed
概括

雌激素受体α (ERα) 的上调会损害自身免疫性肝炎 (AIH) 中的调节性T细胞 (Treg) 功能,特别是在绝经前妇女中. 阻止ERα稳定Tregs并减少肝炎,为AIH提供了潜在的治疗方法.

关键词:
自体免疫性肝炎的发生.雌激素受体-阿尔法缺氧诱导因子1-αα.监管T细胞的监管性T细胞

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