Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Magical Thinking01:29

Magical Thinking

195
Magical thinking encompasses the belief in assumptions that defy logical reasoning yet appear intuitively convincing. It is a common psychological phenomenon that persists across various cultural and individual contexts. While these assumptions contradict empirical evidence and scientific laws, they often serve meaningful psychological roles in promoting emotional resilience and a sense of control, especially under stress or uncertainty.Thought-Action Fusion and the Law of SimilarityA key...
195
Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning07:33

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

12.9K
This technique enables the use of high-resolution magic angle spinning proton MR spectroscopy (HRMAS 1H-MRS) for molecular characterization of live Drosophila melanogaster with a conventional 14.1 tesla spectrometer equipped with an HRMAS...
12.9K
High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

6.0K
The molecular structures and dynamics of solids, liquids, gases, and mixtures are of critical interest to diverse scientific fields. High-temperature, high-pressure in situ MAS NMR enables detection of the chemical environment of constituents in mixed phase systems under tightly controlled chemical...
6.0K
In Utero Electroporation of Multiaddressable Genome-Integrating Color (MAGIC) Markers to Individualize Cortical Mouse Astrocytes06:47

In Utero Electroporation of Multiaddressable Genome-Integrating Color (MAGIC) Markers to Individualize Cortical Mouse Astrocytes

6.0K
Astrocytes tile the cerebral cortex uniformly, making the analysis of their complex morphology challenging at the cellular level. The protocol provided here uses multicolor labeling based on in utero electroporation to single out cortical astrocytes and analyze their volume and morphology with a user-friendly image analysis...
6.0K
Cryogenic Sample Loading into a Magic Angle Spinning Nuclear Magnetic Resonance Spectrometer that Preserves Cellular Viability06:42

Cryogenic Sample Loading into a Magic Angle Spinning Nuclear Magnetic Resonance Spectrometer that Preserves Cellular Viability

3.8K
Presented here is a protocol for cryogenic transfer of frozen samples into the dynamic nuclear polarization (DNP) magic angle spinning (MAS) nuclear magnetic resonance (NMR) probe. The protocol includes directions for rotor storage prior to the experiment and directions for viability measurements before and after the...
3.8K
Preparation of Gene Gun Bullets and Biolistic Transfection of Neurons in Slice Culture17:42

Preparation of Gene Gun Bullets and Biolistic Transfection of Neurons in Slice Culture

53.2K
We describe a method for preparing DNA coated gold bullets and demonstrate the use of such bullets to biolistically transfect neurons in cultured hippocampal slices.
53.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Aminoacyl-tRNA synthetase: A 'semiotic enzyme'.

European journal of medical genetics·2025
Same author

Integrating patient and public involvement during the COVID-19 pandemic: lessons from COVID-clinical neuroscience study.

Research involvement and engagement·2025
Same author

Characterisation of the fig-fig wasp holobiont.

Bio Systems·2024
Same author

A determination of pan-pathogen antimicrobials?

Medicine in drug discovery·2022
Same author

Broad-spectrum therapeutics: A new antimicrobial class.

Current research in pharmacology and drug discovery·2021
Same author

Azithromycin: The First Broad-spectrum Therapeutic.

European journal of medicinal chemistry·2020

相关实验视频

Updated: Jan 20, 2026

Magical Thinking
01:29

Magical Thinking

Published on: September 18, 2025

195

魔法子弹,魔法盾牌,以及中间的抗菌药物.

Praveen Prathapan1

  • 1New Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

Pharmaceutical science advances
|January 19, 2026
PubMed
概括

这项研究引入了免疫调节性抗微生物药物 (IAs),这是一个新的药物类别,结合了杀死病原体和免疫调节作用. 由于它们对多种病原体的多功能性,IA显示出对流行病准备的承诺.

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 传染性疾病 传染性疾病
  • 药物发现 药物发现 药物发现

背景情况:

  • 目前的小分子传染病药物分为两类:病原体导向的抗微生物药物 (抗生素,抗病毒药物) 和宿主导向的免疫调节剂 (皮质类固醇).
  • 需要新的治疗策略来应对新出现的传染病和潜在的流行病.

研究的目的:

  • 提出和定义第三类小分子药物:免疫调节性抗微生物药物 (IAs).
  • 审查现有的小分子药物,具有双重病原体导向和宿主导向药理学.
  • 评估IA在流行病准备研究中的潜力.

主要方法:

  • 对表现出抗微生物和免疫调节活性的小分子药物的文献综述.
  • 将已识别的药物分为七种类型的免疫调节抗微生物药物的分类.
  • 对药物重置性和网络药理学的分析,以获得广泛的疗效.

主要成果:

  • 确定了七种不同类型的免疫调节性抗微生物药物 (IA).
  • IAs具有双重药理学,直接向病原体,同时调节宿主免疫反应.
  • 这些药物表现出高的重置性和网络药理学能力.

结论:

关键词:
免疫调节性抗微生物药物全病原体药理学 泛病原体药理学流行病的准备情况.

更多相关视频

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning
07:33

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

Published on: April 15, 2010

12.9K
High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

6.0K

相关实验视频

Last Updated: Jan 20, 2026

Magical Thinking
01:29

Magical Thinking

Published on: September 18, 2025

195
Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning
07:33

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

Published on: April 15, 2010

12.9K
High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

6.0K
  • 免疫调节性抗微生物药物代表了一种新的,重要的第三类小分子药物用于传染病.
  • 艾滋病毒的固有特性,包括广泛的活性和适应性,使它们非常适合流行病准备.
  • 与传统的抗病毒药物相比,IA在流行病情景中提供了一种更通用的方法来对抗各种病原体.