血清度作为ICU COVID-19患者死亡率的预测指标:一个回顾性分析
Mehmet Toptas1, Özlem Dikme2, Ozgur Dikme2
1Department of Anesthesiology and Reanimation, İstanbul Training and Research Hospital, İstanbul, Fatih, Turkey.
PeerJ
|January 19, 2026
概括
较低的血清度和低血与重症COVID-19患者的住院死亡率较高有关. 血清和度可以帮助这些患者早期风险分层.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
背景情况:
- 血清度反映了液体和电解质平衡,可能作为危急病患者的预后标志物.
- 在2019年冠状病毒疾病 (COVID-19) 中血清度的预后作用尚未得到充分确立.
- 这项研究调查了入院血清度和重症COVID-19患者的住院死亡率之间的关联.
研究的目的:
- 为了评估入院血清度和重症COVID-19患者的住院死亡率之间的关联.
- 为了确定血清度是否可以作为这个人群中死亡率的预后标记.
- 探索血清度,低血量和临床结果之间的关系.
主要方法:
- 对267名进入ICU的重症COVID-19患者进行了回顾性研究.
- 收集的数据包括人口统计,CT发现,血管压缩器使用,通风支持,实验室值和住院死亡率.
- 计算了血清度,统计分析包括后勤回归和ROC曲线分析.
主要成果:
- 在医院的死亡率为76% (203/267).
- 幸存者中位数血清度 (288.37对285.75mOsm/L) 和血清 (135对133mEq/L) 较高.
- 血清 (OR=0.89) 和内内输管 (OR=5.20) 是死亡率的独立预测因素.
结论:
- 较低的入院血清度和低血独立地与重症COVID-19患者的住院死亡率增加有关.
- 血清的分辨率略高于度,但度仍然是一个实际的预后工具.
- 需要进行前性研究,以评估纠正低度或低度状态是否能改善结果.
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