科学家的警告:我们必须改变范式,在毒理学和世界粮食供应方面进行革命
Gilles-Eric Seralini1, Gérald Jungers1, Arden Andersen2
1G.E.S. and G.J. Network On Risks, Quality and Sustainable Environment, University of Caen Normandy, Caen, France.
Environmental sciences Europe
|January 19, 2026
概括
目前的毒理学测试是误导性的,因为完整的农药配方,而不仅仅是活性成分,是更有毒的. 我们建议对农药混合物进行强制性长期测试,并提供公共数据访问,以保护公众和环境健康.
科学领域:
- 环境毒理学环境毒理学
- 化学安全 化学安全
- 监管科学 监管科学
背景情况:
- 自20世纪中叶以来,历史上的毒理学测试实践一直是误导性的.
- 杀虫剂和塑化剂配方含有未披露的石油废物和重金属,对所有生命构成风险.
- 目前的法规不充分评估完整化学配方的毒性,而是依赖于孤立的活性成分.
研究的目的:
- 突出目前对化学配方,特别是杀虫剂和塑化剂的毒理学评估中的严重缺陷.
- 建议在化学安全评估的监管方法中进行范式转变.
- 通过更严格的测试和数据透明度,倡导加强公共和环境健康保护.
主要方法:
- 对农药和塑化剂的历史和当前毒理学测试协议的分析.
- 活性成分和完整的商业配方之间的毒性数据的比较.
- 审查监管框架和环境法建议.
主要成果:
- 在长期暴露下,农药配方的毒性明显高 (至少是1000倍) 于单独声明的活性成分.
- 监管评估主要集中在单独的活性成分上,忽视了复杂混合物的协同毒性.
- 不完全披露配方成分和不充分的长期测试有助于显著的公共和环境健康风险.
结论:
- 需要对毒理学法规进行根本性的转变,优先考虑对完整化学配方的测试.
- 建议包括降低现有污染物的可接受每日摄入量 (ADI),并要求对新化合物及其完整配方进行慢性体内测试.
- 全面公布原始毒理学数据对于科学进步和公众信任至关重要,支持发展农业生态替代品.
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