海马治疗对平衡表现,神经生理参数和多发性硬化症临床症状的有效性:随机控制多中心研究的研究方案 (MS-HIPPO II - 平衡运动)

Precise measurement of neurological and neuropsychological impairment and disability in multiple sclerosis is challenging. We report methodologic details on a new test, the Multiple Sclerosis Performance Test (MSPT). This new approach to the objective of quantification of MS related disability provides a computer-based platform for precise, valid measurement of MS...

The goal of this pilot study is to describe a protocol for the remotely-supervised delivery of transcranial direct current stimulation (tDCS) so that the procedure maintains standards of in-clinic practice, including safety, reproducibility, and tolerability. The feasibility of this protocol was tested in participants with multiple sclerosis (MS).

Balance and coordination are critical components involved in the control of movement. Many sensory receptors and neural processing units are required to help individuals maintain balance while performing various activities. Deficits in balance and coordination occur in patients suffering from movement disorders or due to aging. Therefore, scientists are trying to understand the pathophysiology behind these conditions. One way to do that is by using rodent models and testing them on behavioral...

This article describes procedures for screening people for standing and walking balance impairments using two normed, rapid, low-tech balance tests.

Multiple sclerosis is an inflammatory demyelinating disease with no cure. Analysis of brain tissue provides important clues to understanding the pathogenesis of the disease. Here we discuss the methodology and downstream analysis of MS brain tissue collected through a unique rapid autopsy program in operation at the Cleveland...

Deficits in fine motor coordination can be assessed with the balance beam test. Performance on the beam is quantified by the speed at which the beam is traversed and the number of times the mouse slips on the...