eVGeMdb:为经过实验验证的神经退行性疾病的遗传修饰剂提供一个手工策划的数据库
Subashani Singh1, Pratibha Singh1, M P Varada1
1Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana 502284, India.
NAR molecular medicine
|January 19, 2026
概括
研究人员创建了eVGeMdb,这是神经退行性疾病 (NDs) 遗传修饰者的数据库. 该资源巩固了碎片化的知识,有助于研究疾病机制和潜在的治疗点.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 生物信息学是一种生物信息学.
背景情况:
- 基因修饰剂通过与主要疾病基因相互作用,影响疾病的发病和进展.
- 对神经退行性疾病 (NDs) 的基因修饰剂的知识目前在各种实验模型中分散.
研究的目的:
- 开发eVGeMdb,一个全面的,手工策划的数据库,用于主要的NDs实验验证的基因修饰剂.
- 整合来自不同模型系统的修饰器数据,进行跨疾病和模型特定的比较.
主要方法:
- 从科学文献中手动整理基因修饰剂数据.
- 整合来自模型系统的信息,包括*Drosophila melanogaster*,*Caenorhabditis elegans*,*Saccharomyces cerevisiae*,细胞模型和小鼠.
- 标注条目与实验上下文,功能信息,人类正义词和网络/路径链接.
主要成果:
- eVGeMdb是一个全面的数据库,拥有超过17,000个对NDs的基因修饰剂的条目.
- 数据库包括氨基缩侧面硬化症,阿尔茨海默病,帕金森病,亨廷顿病和其他疾病的修饰剂.
- 该资源有助于识别通用和疾病特异性修饰剂.
结论:
- eVGeMdb为神经退行性疾病遗传修饰剂研究提供了一个集中,可访问的平台.
- 该数据库支持假设生成,实验验证和疾病病理生理学的调查.
- 该资源有助于研究人员了解神经退行性疾病复杂的遗传情景.
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