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TRMT112的高表达与口腔状细胞癌的发展有关

Anitha Pandi¹, Premkumar Rajendhiran², Vijayashree Priyadharsini Jayaseelan¹

¹Clinical Genetics Lab, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.

Journal of oral biology and craniofacial research

|January 19, 2026

概括

转移RNA (tRNA) 甲基转移酶112 (TRMT112) 在口腔状细胞癌 (OSCC) 中被上调. 升高的TRMT112与预后不佳相关,并表明它是OSCC的潜在治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

转移RNA (tRNA) 甲基转移酶112 (TRMT112) 失调与人类的癌症发生有关.
口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
了解TRMT112在OSCC中的作用对于开发新的治疗策略至关重要.

研究的目的:

为了研究TRMT112在OSCC组织中的表达水平.
分析TRMT112在临床病理特征和患者预后方面的临床意义.
探索TRMT112作为OSCC的预后和治疗点的潜力.

主要方法:

在配对的瘤和非瘤OSCC组织中对TRMT112表达的定量实时PCR (qPCR) 和西部斑分析.
对TCGA-HNSCC数据集 (UALCAN,人类蛋白质图谱,TIMER2.0) 的生物信息分析,以将TRMT112表达与临床病理特征,预后,免疫透和免疫治疗反应相关联.
功能性丰富分析以阐明TRMT112.2.的致癌作用和分子机制.

主要成果:

与相邻的非瘤组织相比,OSCC组织中TRMT112表达显著上调.
上调的TRMT112表达与晚期瘤阶段,转移,免疫透减少和患者预后较差有关.
根据蛋白质网络和通路丰富分析,TRMT112与参与口腔癌进展的已知上蛋白相互作用.

结论:

TRMT112在OSCC的瘤发生中发挥着重要作用.
对于OSCC患者来说,TRMT112是潜在的预后生物标志物.
TRMT112是OSCC治疗的有前途的治疗候选药物.

关键词:

死亡率死亡率死亡率这是OSCCCC的OSCC.预测预后预测预测 TRMT112 需要注意的是治疗目标是治疗的目标.

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