在鼻癌中强度调节的质子疗法与强度调节的放射疗法:一个病例控制研究
Caineng Cao1,2, Teeradon Treechairusame2,3, Amir H Safavi2
1Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
强度调节的质子疗法 (IMPT) 对鼻癌 (NPC) 患者的急性毒性低于强度调节的放射疗法 (IMRT). 在两种治疗方式之间,长期结果和晚期毒性是相似的.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 鼻癌 (NPC) 治疗涉及复杂的放射治疗技术.
- 强度调节质子疗法 (IMPT) 和强度调节放射疗法 (IMRT) 是先进的辐射方式.
- 需要对IMPT与IMRT对NPC的长期数据进行比较.
研究的目的:
- 评估和比较长期毒性和生存结果.
- 评估IMPT与IMRT在最终NPC治疗中的有效性和安全性.
- 分析来自高等学术癌症中心 (2016-2022) 的数据.
主要方法:
- 追溯队列研究,包括67例IMPT和92例IMRT病例.
- 随访时间中位数为55.4个月.
- 对急性毒性进行后勤回归分析.
主要成果:
- IMPT显示,2级+急性毒性的发生率显著降低 (86.6%对97.8%,p=0.009).
- 2级+晚期毒性 (40.3%与52.7%相比,p>0.05) 没有显著差异.
- 在IMPT和IMRT组之间,类似的5年地方/区域失败率,无进展生存率和整体生存率.
结论:
- 与NPC的IMRT相比,IMPT与急性毒性降低有关.
- 长期瘤结果和晚期毒性概况在IMPT和IMRT之间是可比的.
- 对于NPC患者来说,IMPT可能在急性毒性降低方面具有优势.
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