丸激素替代疗法与男性近腰骨折发生率之间的关系:一个匹配的回顾分析
Paul-Hugo Arcand1,2, Simbarashe J Peresuh1,2, Joseph Confessore1,2
1Department of Orthopaedic Surgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
JSES reviews, reports, and techniques
|January 19, 2026
概括
替代疗法 (TRT) 与男性近腰骨折 (PHF) 的更高发病率有关. 这项研究发现,TRT使用与两年内PHF风险显著增加有关.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 替代疗法 (TRT) 治疗阴性腺体缺陷症,并影响骨密度.
- TRT与骨折风险之间的联系,特别是近腰骨折 (PHF),尚未得到充分证实.
- 已知使用类固醇类固醇会增加肌破裂的风险.
研究的目的:
- 评估TRT与近腰骨骨折 (PHF) 的发生率之间的关联.
- 调查丸激素在骨健康中的作用及其对骨折风险的潜在影响.
- 为了比较接受TRT的男性与对照组的PHF发病率.
主要方法:
- 使用PearlDiver Mariner165数据集进行的回顾性匹配队列研究.
- 根据年龄,吸烟,糖尿病和并发症,对335,753对TRT患者和对照进行了匹配.
- 使用ICD代码和后勤回归分析评估PHF的2年发病率.
主要成果:
- 与对照组 (0.005%) 相比,TRT患者的PHF发病率较高 (0.029%).
- TRT与PHF风险增加显著相关 (aOR 3.14,95% CI:1.84至5.59).
- 这一关联在统计学上仍然显著 (P < .001).
结论:
- 在男性中,TRT使用与近接骨骨折的2年发病率增加有关.
- 这些发现表明需要量身定制的患者管理,并为骨科实践提供信息.
- 需要进一步的前性研究来确定因果关系并探索混因素.
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