交通噪音污染作为心血管风险因素:从流行病学证据到机械洞察力
Thomas Münzel1, Marin Kuntic1, Michael Molitor1
1University Medical Center Mainz, Department of Cardiology, Mainz, Germany.
EXCLI journal
|January 19, 2026
概括
交通噪音是一个重要的心血管风险因素,每年导致数百万健康生命年丧失. 这种暴露会触发压力反应,导致血管炎症并加速血管衰老.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 交通噪音是一种广泛的环境暴露,影响了欧洲超过1.13亿人.
- 慢性噪音暴露与心血管疾病有关,包括缺血性心脏病,心力衰竭,中风和2型糖尿病.
- 噪音污染对公众健康造成重大负担,每年在欧洲损失约130万健康寿命年.
研究的目的:
- 确定交通噪音是主要的心血管风险因素.
- 阐明将噪音暴露与心血管疾病联系在一起的生物机制.
- 为公众健康政策和关于噪音污染的预防指南提供信息.
主要方法:
- 流行病学研究表明噪音暴露与心血管结果之间的关联.
- 翻译和实验研究研究这些关联的生物学可信性.
- 分子和神经成像研究检查噪音对压力路径,基因表达和大脑活动的影响.
主要成果:
- 一致的流行病学证据将交通噪音与缺血性心脏病,心力衰竭,中风,2型糖尿病,高血压,心房动和肥胖有关.
- 暴露于噪音会激活交感神经系统和下丘脑-垂体-上腺轴,导致内皮功能障碍,血管炎症和氧化应激.
- 分子机制包括改变基因表达,扰乱昼夜节律和亲炎性表观遗传修饰,神经成像显示杏仁体激活.
结论:
- 交通噪音是已确定的心血管风险因素,需要优先考虑公共卫生.
- 噪音诱导的压力路径与传统的心血管风险因素重叠,表明血管衰老加速.
- 对噪音和空气污染的联合暴露可能具有附加性或协同性的不利影响,突出了暴露组概念.
相关概念视频
10:11Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
19.6K
Retinal image analysis is an unobtrusive procedure for visualizing the microcirculation. The impact of cardiovascular disease risk factors can result in changes of retinal vessel calibers. The procedures to acquire fundus images and the steps for calculating the vessel calibers are...
19.6K
01:26Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
02:55The Evidence for Evolution
47.6K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
47.6K
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
8.0K
This article presents a protocol based on Hydra — a web-based system for clinical decision support that integrates a full and detailed set of functionalities and services required by physicians for complete cardiovascular analysis, risk assessment, early diagnosis, treatment, and monitoring over...
8.0K
06:04Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
1.4K
Endothelial/vascular aging and atherogenesis are key mechanisms that promote the development of cardiovascular diseases. The present protocol describes methods to evaluate arterial stiffness, endothelial dysfunction, and atherogenesis in patients with related risk factors, which are highly valuable in the cardiovascular research...
1.4K
08:50In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors
8.6K
Fungicide sprays on flowering plants may expose solitary bees to high concentrations of pollen-borne fungicide residues. Using laboratory-based experiments involving in vitro-reared bee larvae, this study investigates the interactive effects of consuming fungicide-treated pollen derived from host and non-host...
8.6K