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Updated: Jan 20, 2026

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综合增强与顺序方案在体积调制弧线疗法 (VMAT) 的三路膀癌疗法:一个比较研究
Reyzane El Mjabber1,2, Rim Alami1,2, Fatimaezzahra Aouzah1,2
1Radiation Oncology, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, MAR.
Cureus
|January 19, 2026
概括
同时整合增强 (SIB) 和顺序增强 (SEQ) 体积调制弧线疗法 (VMAT) 对于肌肉侵入性膀癌 (MIBC) 的膀保存有效. SIB提供更快的治疗,而SEQ可能更好地省略小肠.
科学领域:
- 辐射瘤学 辐射瘤学
- 尿道瘤学 尿道瘤学
背景情况:
- 三式治疗 (TMT) 是一种用于肌肉侵入性膀癌 (MIBC) 的膀保护方法.
- 卷度调制弧线疗法 (VMAT) 允许使用先进的放射治疗剂量递送技术,包括同时集成增强 (SIB) 和顺序增强 (SEQ).
研究的目的:
- 为了在接受TMT的MIBC患者中比较SIB-VMAT和SEQ-VMAT之间的剂量测量结果,危险器官节省和治疗耐受性.
- 评估不同VMAT剂量输送方案的有效性和安全性,以保护膀.
主要方法:
- 对14名接受TMT (SIB-VMAT或SEQ-VMAT) 治疗的MIBC患者的回顾性分析.
- 对直肠,小肠和股骨头的剂量-体积参数的评估.
- 使用CTCAE v6.0标准评估瘤反应和毒性.
主要成果:
- SIB和SEQ都实现了可比的目标覆盖率和符合性.
- 直肠和股骨头的剂量相似;SIB-VMAT导致小肠剂量更高 (V15Gy,V45Gy).
- 急性毒性主要是1-2级尿路,SIB组的完全响应率略高一些.
结论:
- 在MIBC中,SIB-VMAT和SEQ-VMAT都对膀保存有效且耐受良好.
- SIB-VMAT提供更短的治疗时间和更好的合规性,而SEQ-VMAT可能提供更好的小肠节省.
- 治疗选择应根据患者解剖学和临床专业知识进行个性化选择.
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