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Updated: Jan 20, 2026

Murine Renal Transplantation Procedure

Murine Renal Transplantation Procedure

Published on: July 10, 2009

基于免疫吸收的脱敏化与柱子重用在ABO不兼容的活体捐赠者移植中

Pranjal Kashiv¹, Mohit Kurundwadkar¹, Prasad Gurjar¹

¹Nephrology, Jawaharlal Nehru Medical College, Wardha, IND.

|January 19, 2026

概括

在免疫吸附 (IA) 中重复使用结构化柱子用于ABO不相容的移植 (ABOi-KT) 是安全有效的. 这种节省成本的方法使得成功的消毒能够实现,扩大了在资源有限的环境中获得移植的机会.

科学领域:

腎病學和免疫學腎病學和免疫學
移植医学移植医学
医疗技术医疗技术医学技术

背景情况:

ABO不兼容移植 (ABOi-KT) 对于扩大活体供体移植至关重要,特别是在已故供体选择有限的地方.
免疫吸附 (IA) 有效地去除抗体,但单次使用列的高成本阻碍了其在资源有限的环境中使用.
结构化列重复使用为基于IA的脱敏感化协议提供了一个潜在的节省成本的解决方案.

研究的目的:

评估基于免疫吸收的脱敏化方案的临床安全性,免疫疗效和实际可行性,使用计划的列重复使用.
在成本受限制的环境中,评估结构化柱子重复使用在ABO不兼容移植中的有效性.

主要方法:

在2023年6月至2025年5月期间接受活体供体ABOi-KT的13名成年患者的回顾性分析.
脱敏涉及免疫吸附 (IA) 在经过验证的无菌条件下选择性列重复使用.
采用标准化免疫抑制和串行异凝素标位监测;结果包括标位降低,移植功能,抗体反弹和并发症.

主要成果:

进行了35个IA会议,其中60%使用了重复使用的列.
所有患者在移植前都达到目标IgG和IgM标位 (≤1:8);12名患者表现出即时的移植功能,平均分泌肌氨酸水平为1.07 mg/dL.
没有发生抗体中介排斥,异聚氨反弹或重复使用相关的不良事件;三个月后100%的患者和移植存活率.

结论:

结构列重复使用的免疫吸附是一种安全,有效和实用的 ABOi-KT.KT 脱敏化策略.
这种方法为资源有限的医疗保健系统提供了可行且具有成本效益的解决方案,旨在增加移植接入.

关键词:

对于移植来说,没有移植.列重复使用列重复使用脱敏感化脱敏感化免疫吸附和吸收的方法血相结合 (plasmapheresis) 是一个过程.

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