在Upadacitinib discontinuation之后,在患有无氧性皮肤炎的患者中发生败血症
John A Gallagher1, Diego Aragón-Caqueo2, Arhum Mahmood3
1Department of Internal Medicine, Wayne State University School of Medicine, Detroit, USA.
对严重的亚托皮性皮炎 (AD) 治疗的准入至关重要. 患者支持计划 (PSP) 有助于维持对像上达西提尼布这样的免疫调节剂的获取,防止严重的复发和并发症.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病.
- 严重的AD可能需要全身免疫调节.
- 雅努斯激酶 (JAK) 抑制剂,如阿帕达西丁,是有效但昂贵的治疗方法.
研究的目的:
- 突出患者支持计划 (PSP) 在维持严重的亚托皮性皮肤炎治疗连续性的关键作用.
- 为了说明由于缺乏保险覆盖而导致治疗中断的严重后果.
主要方法:
- 一个年轻人患有严重AD的案例报告.
- 治疗中止和随后的疾病复发的分析.
- 审查保险覆盖损失对药物获取的影响.
主要成果:
- 由于失去了保险覆盖,停止服用upadacitinib导致严重的AD复发.
- 复发包括细胞炎,败血症和急性肝衰竭.
- 患者支持计划 (PSP) 对治疗坚持至关重要.
结论:
- 维持对全身免疫调节剂的获取对于严重的AD管理至关重要.
- 患者支持计划 (PSP) 对于预防严重并发症至关重要.
- 解决成本和保险障碍对于有效的AD治疗至关重要.
相关概念视频
06:47Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Discontinuing Intravenous Fluids and a Peripheral Intravenous Line
Intravenous (IV) fluid administration and peripheral IV catheters (PIVs) may be discontinued for a number of reasons. The most common reason for discontinuing IV fluids is that the patient has returned to normal body fluid volume (euvolemia) and is able to maintain adequate oral fluid intake or is being discharged from the hospital. In addition, the Centers for Disease Control Guidelines...
07:42A Data-Driven Approach to Quantifying Immune States in Sepsis
04:01A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
06:40Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice

