布伊-辛-申配方通过PI3K-Akt/NF-κB信号在皮肤外科冠状动脉干预后心痛中向单细胞
Chunxiao Su1, Jinghui Bai2, Xiaomin Jiao3
1Liaoning University of Traditional Chinese Medicine Shenyang 100029, Liaoning, China.
American journal of translational research
|January 19, 2026
概括
布伊辛申配方 (BYXSF) 通过向PI3K-Akt和NF-κB通路中的关键基因来治疗皮肤穿透后冠状动脉干预 (PCI) 后心痛. 单细胞被确定为通过 BYXSF 调解的主要细胞类型.
科学领域:
- 传统中国医药 传统中国医药
- 心血管药理学心血管药理学
- 生物信息学是一种生物信息学.
背景情况:
- 布伊辛申配方 (Bu-Yi-Xin-Shen formula,简称BYXSF) 是一种用于皮肤穿后冠状动脉干预 (PCI) 心痛的传统药物.
- 了解BYXSF的分子机制对于优化其治疗应用至关重要.
研究的目的:
- 阐明BYXSF在治疗PCI后心脏病的作用机制.
- 确定BYXSF的关键治疗点和活性成分.
主要方法:
- 生物信息分析包括PPI网络和功能丰富.
- 分子对接用于活性成分识别和毒性评估.
- 单细胞RNA测序 (scRNA-seq) 用于细胞类型和基因表达分析.
- 在体内验证已识别的途径.
主要成果:
- 显著丰富PI3K-Akt和NF-κB信号通路.
- 已经确定了主要目标:PIK3R1,PIK3CA,PIK3CB,EGFR,AKT1,SRC.
- 确定了五种活性成分 (甲,甲,液原蛋白,性角素,德尔托因).
- 单细胞被确定为介导BYXSF效应的核心细胞类型.
- 在体内研究证实了BYXSF在调节向通路方面的有效性.
结论:
- 通过调节PI3K-Akt和NF-κB通路,BYXSF可以缓解PCI后心痛.
- 其中PIK3R1,PIK3CA,PIK3CB,EGFR,AKT1和SRC是关键的基因.
- 单细胞被确定为BYXSF治疗的主要细胞标.
- 这项研究为BYXSF.的临床开发提供了基础.
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