协议和统计分析计划,用于血栓压素的毒冲击实证 (VASSPR) 集群交叉随机试验
Ithan D Peltan1, Danielle Groat1, Jason R Jacobs1
1Department of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
压素用于败血性休克实用 (VASSPR) 试验调查了败血性休克的最佳压素启动值. 这项实用性试验旨在确定较低或较高的值是否会影响重症患者的28天死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 目前的指导方针推加压素作为一种首选的二线药物用于感染性休克管理.
- 输血压素启动的最佳时间仍然是临床不确定性的领域.
研究的目的:
- 为了比较较低与较高的血管压素启动值对性休克患者28天死亡率的疗效.
- 为了评估不同的血管压素启动策略对无置换疗法的影响.
主要方法:
- 消毒冲击实用性血管压素 (VASSPR) 试验是一项多中心,集群随机化,实用性临床试验.
- 它比较了在较低的值 (0.1 mg/kg/min NEEs) 和更高的值 (0.4 mg/kg/min NEEs) 启动血管压素.
- 主要结局是28天的全因死亡率,关键的次要结局是无置换治疗的日子.
主要成果:
- 本文详细介绍了VASSPR试验的协议和统计分析计划.
- 关于主要和次要结局的结果正在等待试验完成.
结论:
- 该VASSPR试验旨在提供关键数据,以优化毒性休克时的血管压缩剂管理.
- 严格的试验进行和预先规定的统计分析对于可靠的发现至关重要.
更多相关视频
相关概念视频
03:26Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:53Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Statistical Software for Data Analysis and Clinical Trials
08:36The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
Statistical Significance
Statistical Analysis: Overview
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...


