相关实验视频

Updated: Jan 20, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

在NIR-II FI-PAI-MRI三模成像中提高性能的新型协同策略

Haoli Yu¹, Yayi Zhang¹, Xinyao Du¹

¹Department of Biotechnology, School of Medical Technology, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China.

|January 19, 2026

概括

这项研究开发了一种新型的三模成像探头,它结合了近红外II光,光声成像和磁共振成像. 该探头通过协同效应提高了成像性能,提供了更清晰的血管结构可视化.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
纳米技术纳米技术

背景情况:

像MRI这样的传统成像技术在时间分辨率和分子灵敏度方面存在局限性.
新兴的模式,如光成像 (FI) 和光声成像 (PAI) 提供高灵敏度,但受限于组织透深度.
整合多种成像模式可以克服个人的局限性,从而提高诊断能力.

研究的目的:

开发一个多功能协同增强战略,以实现先进的成像性能.
构建一个三模成像探头,同时进行近红外II (NIR-II) 光,光声成像 (PAI) 和磁共振成像 (MRI).
研究共同封装剂的协同效应,以改善成像结果.

主要方法:

制造一个三种模式的成像探头,同时封装ICG (NIR-I光体),IR-1061 (NIR-II光体) 和超小的硫化铜量子点 (u-Cu2-xS QD).
调查ICG和IR-1061之间的Förster共振能量转移 (FRET),以增强NIR-II光.
评估IR-1061的光热特性和与u-Cu2-xS QDs用于PAI增强的协同效应.
评估u-Cu2-xS QDs的MRI特性,并与NIR-II FI和PAI功能进行集成.

主要成果:

同时加载ICG和IR-1061证明了FRET效应,导致NIR-II光性能提高了2倍.
在小鼠体内成像显示出更清晰的血管结构可视化.
探测器由于IR-1061和u-Cu2-xS QDs的光热特性,在PAI性能中表现出协同增强.
集成的多式联络功能弥补了光学成像技术有限的组织透深度.

结论:

开发的三模成像探头成功地集成了NIR-II FI,PAI和MRI功能.
同封装剂之间的协同效应显著提高成像性能,特别是NIR-II光和PAI.
这一战略为推进NIR-II多式成像提供了一个新的设计范式,克服了个别技术的局限性.
该探测器展示了改进诊断成像的潜力,特别是用于深层组织血管可视化.

更多相关视频

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images

Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images

Published on: May 23, 2019

相关概念视频

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

The present protocol describes a detailed, real-time NIR-II fluorescence imaging operation of a mouse using a NIR-II optics imaging...

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

This video illustrates a method, using a clinical 3 T scanner, for contrast-enhanced MR imaging of the naïve mouse visual projection and for repetitive and longitudinal in vivo studies of optic nerve degeneration associated with acute optic nerve crush injury and chronic optic nerve degeneration in knock-out mice...

Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images

Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images

Here, we demonstrate magnetic resonance (MR)-guided convection enhanced delivery (CED) of viral vectors into the cortex as an efficient and simplified approach for achieving optogenetic expression across large cortical areas in the macaque...

Pulmonary Structural MRI using Free-Breathing, Self-Gated Ultra-short Echo Time Imaging

Pulmonary Structural MRI using Free-Breathing, Self-Gated Ultra-short Echo Time Imaging

A protocol is described for generating high-resolution structural images of the lungs using ultra-short-echo time (UTE) Magnetic Resonance Imaging (MRI). This protocol allows for images to be acquired using a simple MRI pulse sequence during free-breathing.

MRI and PET in Mouse Models of Myocardial Infarction

MRI and PET in Mouse Models of Myocardial Infarction

We describe how to perform MRI and PET imaging of the mouse heart. The protocol is tailored to assess treatment efficacy in models of myocardial infarction and heart...

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

The method presented here uses simultaneous positron emission tomography and magnetic resonance imaging. In the cerebral hypoxia-ischemia model, dynamic changes in diffusion and glucose metabolism occur during and after injury. The evolving and irreproducible damage in this model necessitates simultaneous acquisition if meaningful multi-modal imaging data are to be...