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Updated: Jan 20, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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基于结构的发现新型非竞争性IDO1抑制剂通过 conformational选择的发现

Patricio Chinestrad1, Ana Julia Velez Rueda2, Melanie Pérez Küper3

  • 1Laboratorio de Farmacología Molecular, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Roque Sáenz Peña 352, Bernal, Argentina.

In silico pharmacology
|January 19, 2026
PubMed
概括

研究人员通过分析其非活性构造,确定了胺二二氧化酶1 (IDO1) 上的一个新型基位. 这一发现可以通过稳定酶来开发用于癌症治疗的新型IDO1抑制剂.

关键词:
这就是"Allosterism".癌症 癌症 癌症 癌症构造的多样性 构造的多样性药物设计 药物设计标签: 标签: IDO1 标签: IDO1 标签: IDO1人口迁移的人口迁移

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