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Updated: Jan 20, 2026

Prevalence and Incidence

Prevalence and Incidence

七号因子缺乏症比以前报告的更为普遍

Lukas Löwing Svensson¹, Elisabeth Aardal¹, Margareta Holmström²

¹Departments of Clinical Chemistry and Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Research and practice in thrombosis and haemostasis

|January 19, 2026

概括

瑞典奥斯特戈特兰的VII因子缺乏症比以前想象的要普遍得多. 大约43%的受影响成年人经历了自发出血,突出了显著的健康问题.

科学领域:

血液学血液学血液学
遗传学遗传学是一个
流行病学流行病学

背景情况:

据估计,在全球范围内,因子VII (FVII) 缺乏的患病率为50万分之一.
低FVII活动 (FVII:C) 经常在瑞典奥斯特戈特兰州观察到.

研究的目的:

为了确定在瑞典奥斯特戈特兰的成年人中FVII缺乏症的患病率.
评估FVII缺乏和低FVII水平的成年患者的出血倾向.

主要方法:

以2017-2022年实验室数据为依据的回顾性横截面研究.
已识别的成人患者FVII:C ≤0.50千IU/L.
将患者分类为FVII缺乏 (<0.35 kIU/L) 或低FVII水平 (0.35-0.50 kIU/L),并评估出血症状.

主要成果:

确定了97名FVII:C ≤0.50千IU/L的患者.
患有FVII缺乏症 (≥0.35 kIU/L) 的患病率至少为1在17,800名成年人中;低FVII水平 (0.35-0.50 kIU/L) 是1在9600人中.
患有FVII缺乏症的患者比患有低FVII水平的患者显示出明显更多的出血症状 (P=.01).

结论:

在奥斯特戈特兰,FVII缺陷的患病率至少为1在17,800,比国际估计高28倍.
在该地区43%的FVII缺乏个体中发生了自发出血.
该研究突出显示,在奥斯特戈特兰,患病率高于预期,相关出血风险较高.

关键词:

血液凝固的因素是血液凝固的因素.第七因子缺乏症是什么?静血性疾病静血性疾病患病率的流行情况.罕见的疾病罕见的疾病

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