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在胺诱导解离中,大脑状态动态与创伤后应激障碍中相似
Noam Goldway1,2,3, Taly Markovits1, Naomi Fine1,4
1Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Biological psychiatry global open science
|January 19, 2026
概括
创伤后应激障碍 (PTSD) 的离散状态涉及改变的大脑动态,特别是增加默认模式网络 (DMN) 活动和减少体运动网络 (SOM) 活动. 对PTSD相关解离的治疗使这些神经模式正常化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算生物学 计算生物学
背景情况:
- 分离,脱离自我和环境,是创伤后应激障碍 (PTSD) 的一个关键特征.
- 解离的神经认知基础尚未得到充分理解,这阻碍了PTSD诊断和治疗.
- 了解这些机制对于改善PTSD治疗结果至关重要.
研究的目的:
- 通过网络控制理论研究离散状态的神经动态.
- 为了比较健康志愿者的胺诱导解离过程中的大脑活动与患有PTSD的患者.
- 检查PTSD患者解离性症状干预措施的影响.
主要方法:
- 将网络控制理论应用于静止状态功能磁共振成像 (fMRI) 数据.
- 研究了30名接受胺治疗的健康志愿者和78名接受治疗的PTSD患者.
- 分析了默认模式网络 (DMN) 和体运动网络 (SOM) 的元状态和大脑的变化.
主要成果:
- 胺胺诱导的解离反映了以前未接受治疗的PTSD患者的大脑动态,显示DMN增加和SOM元态主导性减少.
- 在PTSD患者治疗后减少的DMN主导与减少的离散症状相关.
- 在治疗后,PTSD患者表现出更有组织,更少的脑状态,尽管胺没有显著改变.
结论:
- 分离状态,无论是药理上诱导的还是临床上存在的,都有共同的神经特征.
- 这些状态的特点是DMN元状态的占主导地位较高,SOM元状态的占主导地位较低.
- 针对PTSD分离症状的干预措施可能会恢复更有组织的神经动态.
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