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Updated: Jan 20, 2026

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来自肠道微生物的硫转移酶对各种硫酸盐化合物起作用,包括乙氨基硫酸盐

Rylee Close^1,2,3, Schuyler Kremer^4,5, Madison Mitchem^1,3

¹Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.

|January 19, 2026

概括

肠道微生物拥有多功能硫转移酶 (ASSTs),可处理化合物,可能有助于宿主排毒. 这些酶与人类酶不同,不需要PAPS,并且具有广泛的基质灵活性.

科学领域:

微生物学微生物学
生物化学生物化学
代谢过程中的代谢.

背景情况:

硫化是真核生物中关键的II期解毒途径,将非极性化合物转化为水友性代谢产物.
人类硫转移酶利用3'-adenosine 5'-phosphosulfate (PAPS) 作为硫供体,但微生物硫转移酶使用未知的供体.
微生物ASST在宿主排毒中的基质和作用在很大程度上仍未被探索.

研究的目的:

为了研究肠道微生物硫转移酶 (ASST) 的基质偏好和潜在贡献,从*Bacteroides vulgatus*到硫化化学.
了解微生物ASST在处理与宿主相关的化合物的多功能性.

主要方法:

酶表征 *Bacteroides vulgatus* ASST. 的酶表征.
对各种化合物的基质接受和产品形成进行了体外分析.
由微生物酶调节的硫酸盐的量化.

主要成果:

*Bacteroides vulgatus* ASST证明了广泛的基质灵活性,可以接受广泛的化合物.
该酶催化了多种的硫化,包括p-酸,p-cresol和 tyramine.
它在体外调节了酸盐度,如乙胺硫酸盐和p-cresol硫酸盐.

结论:

肠道微生物ASST是多功能催化剂,能够硫化各种宿主遇到的分子.
这些微生物酶可能在宿主脱毒中发挥重要作用,补充人类的硫转移酶.
需要进一步的体内研究,以阐明ASSTs对宿主排毒过程的确切贡献.

关键词:

乙氨基的使用方法细菌类菌体的存在我们的肠道微生物组.对于p-cresol来说,这是一个很好的方法.硫酸转移酶的使用方法

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