赛马福林7A通过PDK1/SGK3/YTHDC1轴介导的血管光滑肌细胞的表型切换加剧腹腔大动脉动脉瘤

Fengchan Li1,2, Zhen Zhu1, Fan Tang1

  • 1Cyrus Tang Medical Institute, Soochow University, Suzhou, China.

Cardiovascular research
|January 19, 2026
PubMed
概括

赛马福林7A (SEMA7A) 通过促进血管光滑肌细胞 (VSMC) 切换,对腹腔大动脉动脉瘤 (AAA) 的发展至关重要. 抑制SEMA7A在预防和治疗AAA方面显示出有前途.

相关概念视频

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Vascular calcification is an important predictor of and contributor to human cardiovascular disease. This protocol describes methods for inducing calcification of cultured primary vascular smooth muscle cells and for quantifying calcification and macrophage burden in animal aortas using near-infrared fluorescence...
20.2K
Porcine Model of Infrarenal Abdominal Aortic Aneurysm11:13

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

This novel model creates robust infrarenal abdominal aortic aneurysms in swine using a combination of balloon angioplasty, elastase/collagenase perfusion, topical elastase application, and oral compound β-aminopropionitrile administration, which interferes with collagen...
9.8K
Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase10:23

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase

This video shows how to induce abdominal aortic aneurysms (AAA) in mice via transient intraluminal infusion of porcine pancreatic elastase into the infrarenal segment of the abdominal aorta. The model has the ability to add broad insight into the pathobiology of AAA due to the emergence of numerous transgenic and gene knockout...
25.2K
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

This protocol describes a calcium phosphate-induced abdominal aortic aneurysm (AAA) mouse model to study the pathological features and molecular mechanisms of...
4.4K
Quantitative Strain Mapping of an Abdominal Aortic Aneurysm10:24

Quantitative Strain Mapping of an Abdominal Aortic Aneurysm

Source: Hannah L. Cebull1, Arvin H. Soepriatna1, John J. Boyle2 and Craig J. Goergen1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana
2Mechanical Engineering & Materials Science, Washington University in St. Louis, St Louis, Missouri
The mechanical behavior of soft tissues, such as blood vessels, skin, tendons, and other organs, are strongly influenced by their composition of elastin and collagen, which provide elasticity and strength. The fiber...
5.0K
Near-infrared Fluorescence Imaging of Abdominal Aortic Aneurysms10:12

Near-infrared Fluorescence Imaging of Abdominal Aortic Aneurysms

Source: Arvin H. Soepriatna1, Kelsey A. Bullens2, and Craig J. Goergen1
1 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana
2 Department of Biochemistry, Purdue University, West Lafayette, Indiana
Near-infrared fluorescence (NIRF) imaging is an exciting optical technique that utilizes fluorescent probes to visualize complex biomolecular assemblies in tissues. NIRF imaging has many advantages over conventional imaging methods for noninvasive imaging of diseases....
8.9K