Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

20.8K
This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral...
20.8K
CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data07:11

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data

3.3K
We present CorrelationCalculator and Filigree, two tools for data-driven network construction and analysis of metabolomics data. CorrelationCalculator supports building a single interaction network of metabolites based on expression data, while Filigree allows building a differential network, followed by network clustering and enrichment analysis.
3.3K
Functions of Connective Tissues01:17

Functions of Connective Tissues

14.8K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
14.8K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

8.4K
Based on resting-state functional magnetic resonance imaging with Granger causality analysis, we investigated the alterations in the directed functional connectivity between the posterior cingulate cortex and whole brain in patients with Alzheimer's Disease (AD), patients with Mild Cognitive Impairment (MCI), and healthy...
8.4K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

7.6K
The goal of the described approach is to determine at what moments of the paradigm (temporal perspective), and between which regions (spatial perspective), significant reconfigurations in functional connectivity occur on functional magnetic resonance imaging recordings during which a time-locked stimulus is...
7.6K
A Data-Driven Approach to Quantifying Immune States in Sepsis07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

482
This study investigates the immune condition in sepsis by analyzing the quantitative relationships among white blood cells, lymphocytes, and neutrophils in sepsis patients and healthy controls using data visualization analysis and three-dimensional numerical fitting to establish a mathematical model.
482

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

An intrathecal therapeutics clinic for administration of tofersen in amyotrophic lateral sclerosis: A Canadian nurse practitioner and neurologist collaborative model.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same author

Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.

NMR in biomedicine·2026
Same author

Narrative coherence shapes functional connectivity in default mode and frontoparietal networks.

Neuroimage. Reports·2026
Same author

Correction: Data-driven disease subgrouping in ALS: a multicenter cerebral functional connectivity study.

Journal of neurology·2026
Same author

Natural History of Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP): A Retrospective Patient Cohort Study.

Neurology and therapy·2026
Same author

Repeatability of Susceptibility Source Separation Methods in Human Brain: A Single-Site Study at 3 T.

NMR in biomedicine·2026

相关实验视频

Updated: Jan 20, 2026

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

20.8K

在ALS中数据驱动的疾病分组:一个多中心的大脑功能连接性研究.

Avyarthana Dey1,2, Tobias Robert Baumeister3, Karleyton C Evans4,5

  • 1Division of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Journal of neurology
|January 19, 2026
PubMed
概括

这项研究探索了神经成像,以客观地识别肌缩侧面硬化症 (ALS) 患者的子组. 使用功能性MRI的数据驱动方法揭示了与疾病进展相关的独特的大脑连接模式,提供了潜在的生物标志物.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.临床分组是临床分组.临床试验丰富的方法数据驱动的分组数据驱动的分组.

更多相关视频

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.3K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.4K

相关实验视频

Last Updated: Jan 20, 2026

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

20.8K
Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.3K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.4K

科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 生物标志物发现发现

背景情况:

  • 肌缩侧面硬化 (ALS) 在临床上是异质的,使得早期功能障碍的检测具有挑战性.
  • 目前的临床评估方法缺乏共识和客观性,阻碍了对疾病进展的理解.
  • 神经成像提供了一个潜在的客观方法来识别和评估ALS疾病阶段特定的子组.

研究的目的:

  • 将数据驱动的神经成像方法与ALS患者分层的临床标准进行比较.
  • 评估功能连接在识别疾病阶段特定的ALS亚组中的实用性.
  • 评估神经成像作为潜在的客观生物标志物用于ALS患者分层和监测.

主要方法:

  • 在174名ALS患者和165名用休息状态fMRI的对照组中评估大脑功能连接.
  • 用数据驱动的等级聚类和三个临床标准 (Riluzole/Edaravone试验标准,中位数进展率) 分组患者.
  • 评估了功能连接和临床功能 (认知,运动,肺部) 之间的关联.

主要成果:

  • 数据驱动和临床方法都确定了具有不同临床特征的两个子组.
  • 数据驱动的方法揭示了大脑连接性改变的更大空间范围.
  • 观察到的临床和连接性差异取决于所使用的分层方法.

结论:

  • 使用功能性MRI的数据驱动方法显示为ALS患者分层的客观生物标志物具有前途.
  • 这种方法可以识别与疾病阶段相关的临床和脑功能变化.
  • 潜在的应用包括临床试验丰富和监测疾病和治疗进展.