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听力损失Langerhans细胞囊细胞形成:与中枢神经系统后果密切相关

Akira Kaino¹, Kenichi Sakamoto^2,3, Kunihiko Moriya⁴

¹Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.

International journal of hematology

|January 19, 2026

概括

听力损失是朗格汉斯细胞囊细胞症 (LCH) 的永久后果. 这项研究发现,儿童LCH患者的听力损失与中枢神经系统 (CNS) 并发症有显著的关联.

科学领域:

儿科瘤学儿科瘤学
耳鼻喉科耳鼻喉科耳鼻喉科
神经学神经学

背景情况:

听力损失是已知的Langerhans细胞囊细胞症 (LCH) 的永久后果.
在LCH中,听力损失与中枢神经系统 (CNS) 并发症的具体特征和关联尚未得到充分了解.

研究的目的:

研究患有LCH的儿科患者听力损失的特征.
为了确定听力损失和中枢神经系统 (CNS) 相关的永久后果之间的关联在LCH.

主要方法:

对317名患有多系统性或多焦点性骨LCH的儿科患者进行了回顾性分析.
从日本LCH研究小组 -96或 -02试验收集的数据.
评估听力损失的发生率,类型,以及与LCH特征和中枢神经系统并发症的关联.

主要成果:

听力损失发生在2.8%的患者中,低于之前报告的水平.
听力损失与耳部病变和中枢神经系统-PCS有显著的相关性 (p=0.018).
七名患者有感觉神经或混合类型的听力损失,通常是严重或深度和单边的.

结论:

患有LCH相关听力损失的患者需要密切监测中枢神经系统并发症.
患有LCH相关的神经退行症 (ND) 的人需要对感觉神经听力损失的发展进行仔细监测.

关键词:

中央糖尿病无味症 (CID) 是一种糖尿病.听力损失听力损失兰格汉斯细胞的基细胞分裂神经退行发生神经退行.感官神经神经系统

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Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.