作为内分泌干扰剂的二氧化物,在男性在子宫内暴露后对DNA甲基化产生长期影响
Davide Sacco1,2, Paolo Brambilla3,4, Luciano Calzari5
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Minerva endocrinology
|January 19, 2026
概括
在男性中,产前暴露于二氧化与长期的表观遗传变化有关,包括改变的基因甲基化和免疫细胞计数. 这些发现表明潜在的健康风险,与之前的关于精液质量下降和甲状腺功能障碍的观察相一致.
科学领域:
- 环境表观遗传学环境表观遗传学
- 人类健康风险评估
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于内分泌干扰物二氧化,已与不良健康结果有关.
- 之前的研究表明,在子宫内实验性暴露于二氧化会导致表观遗传变化并降低精液质量.
- 在人类中,产前暴露于二氧化的长期表观遗传影响在很大程度上是未知的.
研究的目的:
- 调查在成年男性中产前暴露于二氧化的长期表观遗传影响.
- 为了比较在子宫中暴露于二氧化的男性和未暴露的对照者之间的表观遗传特征.
主要方法:
- 一项病例控制研究,涉及38名暴露于二氧化物和41名未暴露的男性.
- 使用Illumina Infinium甲基化EPIC珠芯片对DNA甲基化的分析.
- 差异甲基化位置 (DMP) 和区域 (DMR) 的识别.
主要成果:
- 暴露个体中观察到SPAG1基因区域的低甲基化和HOXA基因家族的高甲基化.
- 在暴露于二氧化的组中发现了表观遗传漂移的增加,这表明潜在的疾病风险.
- 暴露的男性显示中性粒细胞增加和自然杀手细胞减少,没有显著的表观遗传加快年龄.
结论:
- 这项研究提供了第一个证据,证明在产前暴露于二氧化的男性中存在长期表观遗传修饰.
- 这些发现与已知减少的精液质量和甲状腺功能变化在暴露于二氧化的人群一致.
- 当前背景二氧化水平明显低于与观察到的表观遗传效应相关的水平.
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