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Updated: Jan 20, 2026

Transcutaneous Auricular Vagus Nerve Stimulation on the Human Ear

Transcutaneous Auricular Vagus Nerve Stimulation on the Human Ear

Published on: August 7, 2025

通过皮肤的耳膜虚神经刺激通过改变右脑干和右脑内皮层活动来调解抗抑郁作用,在动物模型中的功能性消化不良

Bowen Feng¹, Shaoyuan Li¹, Ningyi Zou¹

¹Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Neurogastroenterology and motility

|January 19, 2026

概括

通过皮肤进行的耳道迷走神经刺激 (taVNS) 可以缓解功能性消化不良 (FD) 的老鼠的抑郁类行为. 这种非侵入性神经调节影响脑干和小脑中的大脑活动,为FD相关的抑郁症提供了潜在的治疗方法.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
精神病学是一个精神病学.

背景情况:

功能性消化不良 (FD) 通常与抑郁和焦虑并发.
对于与FD相关的情绪障碍而言,通过皮肤进行耳道迷走神经刺激 (taVNS) 的中心机制尚未完全理解.

研究的目的:

在FD的动物模型中研究taVNS对类似抑郁症的行为的影响.
探索与FD和抑郁症相关的大脑活动的taVNS诱导的改变.

主要方法:

使用乙胺 (IA) 测量建立了FD的动物模型.
鼠每天接受14天的taVNS,然后进行行为测试 (OFT,FST).
休息状态功能磁共振成像 (rs-fMRI) 评估了低频波动的幅度 (ALFF) 和区域均性 (ReHo).

主要成果:

taVNS改善了类似抑郁症的行为,增加了OFT得分,并减少了FST不运动.
在右脑干中,taVNS降低了ALFF和ReHo.
taVNS在左小脑分子层增加了ALFF,在右脑内皮层增加了ReHo.

结论:

在FD大鼠中,taVNS有效地减轻了抑郁状态.
治疗效果可能涉及内皮质神经协调增强和抑制脑干活动.
作为与功能性消化不良相关的抑郁症的治疗方法,taVNS显示出希望.

关键词:

大脑干的大脑干抑郁抑郁症抑郁症抑郁症是一种内皮层 (entorhinal cortex) 是一个内侧的皮层.功能性消化不良症功能性消化不良症通过皮肤进行耳部电动漫神经刺激.

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