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Updated: Jan 20, 2026

Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
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Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes

Published on: July 14, 2023

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GMCL1控制了53BP1的稳定性,并调节了税种的敏感性

Yuki Kito1,2, Tania J González-Robles1,3,4, Sharon Kaisari1,2,4

  • 1Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, United States.

eLife
|January 19, 2026
PubMed
概括

GMCL1通过降解53BP1来调节线粒细胞止时钟通路 (MSP),防止p53的稳定. 它的枯竭使得抗帕克利塔塞尔癌症变得敏感,为改善癌症治疗提供了潜在的治疗标.

关键词:
53BP1BP1是什么意思GMCL1 GMCL1 的使用方法癌症生物学 癌症生物学细胞生物学 细胞生物学人类 人类 人类 人类 人类 人类 人类线粒体的时间表.在p53中,p53是什么?长时间的线粒分裂.蛋白质降解 蛋白质降解

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