酒精消费和心房风险:系统审查和网络元分析的概述
MohammadHossein Hadi1, Sanjib Saha2, Dennis Petrie1
1Centre for Health Economics, Monash Business School, Monash University, Melbourne, Australia.
Drug and alcohol review
|January 19, 2026
概括
这项研究揭示了酒精摄入量与心房动 (AF) 风险之间的非线性联系. 建议限制酒精消费,特别是大量饮酒,以减少AF风险,并观察到性别特定的模式.
科学领域:
- 心脏病学和心血管疾病.
- 流行病学和公共卫生.
- 酒精研究 酒精研究
背景情况:
- 酒精消费是心房动 (AF) 的已知危险因素.
- 之前的研究还没有准确地定义不同摄入水平和性别之间的关系.
- 这项研究是关于可归因于酒精的危害的审查的更广泛概述的一部分.
研究的目的:
- 精确量化不同程度的酒精消费与发展心房动 (AF) 的风险之间的关联.
- 调查酒精摄入量与AF风险之间的关系中的性别特异性差异.
- 为减轻AF风险提供基于证据的饮酒建议.
主要方法:
- 对有关酒精和AF风险的现有元分析进行了系统审查.
- 包括来自13项前性队列研究的数据,涵盖超过8000万人年.
- 进行了随机效应网络元分析,包括性别分层分析,以评估风险.
主要成果:
- 适度饮酒量 (12-24g/天) 显示AF风险略有增加 (HR=1.07).
- 过度饮酒 (≥60g/天) 显示出AF风险最高 (HR=2.84).
- 在男性中,中度摄入量略有增加了AF风险,而大量摄入量显著增加了AF风险 (HR=1.49).
- 在女性中,中度摄入没有显著影响,但大量摄入显著增加了AF风险 (HR=2.53).
结论:
- 酒精消费和AF风险之间存在非线性关系.
- 低水平或偶尔饮酒与最低的AF风险有关.
- 性别特定的模式表明,男性更容易受到中等摄入风险的影响,而女性在大量消费时面临更高的风险.
- 建议限制酒精摄入量以减少AF风险,并呼吁提出性别特定的建议.
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