开发和验证磁共振成像引导的适应性放射治疗工作流程,用于长期,连续的规划目标体积.
Lingling Yan1, NingYu Wang1, Ke Zhang1
1Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Technology in cancer research & treatment
|January 19, 2026
概括
这项研究开发了一种新的磁共振成像导向适应性放射治疗 (MRIgART) 工作流程,用于治疗以前无法用MR-Linac治疗的长瘤. 验证的工作流扩展了MRIgART应用程序的扩展规划目标卷 (PTV).
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 磁共振成像技术 磁共振成像技术
背景情况:
- 目前的磁共振 (MR) -Linac系统具有限制场大小的限制,限制了长于20厘米的瘤的治疗.
- 这就需要开发先进的放射治疗技术,以适应更大的目标体积.
研究的目的:
- 开发和验证一种扩展磁共振成像导向适应性放射治疗 (MRIgART) 工作流程,用于治疗长期,持续规划的目标体积 (PTV).
- 为了克服目前MR-Linac扩展PTV的现场尺寸的局限性.
主要方法:
- 拟议的MRIgART工作流将长的PTV划分为具有定义的同心和场重叠区域的子体积.
- 它包含调整的MRI扫描范围,在线/离线自适应程序,同步的自适应过程和治疗前剂量评估.
- 验证使用MR幻影进行,用ArcherQA蒙特卡洛,ArcCHECK幻影和电离室测量进行剂量验证.
主要成果:
- 工作流程证明了在两个临床场景 (ATP和ATS/ATP) 中,在两个临床场景 (减去重叠区域) 中治疗PTV长达40厘米的可行性.
- 适应性计划的平均马通过率很高 (PTV的95.74%98.63%,重叠区域的95.50%).
- 电离室测量显示,与计算结果的差异不到2%,证实了准确性.
结论:
- 开发的MRIgART工作流是可行的,安全的,准确的,用于治疗长时间的PTVs.
- 这一创新有效地扩大了MRIgART的临床适用性,使其适用于需要治疗扩大目标体积的患者.
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