在实体器官移植接受者中快速检测抗菌素耐药性的方法
Eliezer Zachary Nussbaum1,2, Sarah E Turbett3,4,5
1Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
概括
抗菌素耐药性 (AMR) 构成重大威胁,特别是在固体器官移植接受者 (SOTR) 中. 本综述审查了SOTR中AMR的快速诊断测试,强调了它们的性能和临床使用的新兴数据.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 移植医学 移植医学 移植医学
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球卫生问题.
- 固体器官移植接受者 (SOTR) 面临更高的多药耐药性细菌感染风险,导致发病率和死亡率增加.
- 针对AMR的快速诊断测定正在取得进展,并且在一般患者群体中被采用.
研究的目的:
- 审查食品和药物管理局批准的,商业上可用的AMR快速检测测试.
- 总结关于这些测试的性能和临床有用性的当前证据,特别是在SOTR中.
- 为了解决与普通人口相比,SOTR的有限数据.
主要方法:
- 对评估快速AMR检测试验研究的文献综述.
- 专注于食品和药物管理局批准的测试.
- 对有关SOTR种群的数据进行分析.
主要成果:
- 新出现的数据显示,在SOTR中,快速AMR测试的性能和实用性各不相同.
- 对SOTR的证据不如对普通人群的证据那么强大.
- 商业上可用的测试正在越来越多地评估这个弱势群体.
结论:
- 快速AMR检测测试有望改善SOTR的结果.
- 需要进一步的研究才能充分确定SOTR.的性能和临床效用.
- 将这些测试整合到SOTR护理途径中需要仔细评估现有证据.
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