抗黑色素生和抗氧化活性Broussonetia papyrifera的叶子提取物发酵
Bo Dou1, Rui-Qi Wu1, Xiao-Lai Ma1
1School of Pharmacy, Guilin Medical University, Guilin 541199, China.
Journal of Asian natural products research
|January 19, 2026
概括
微生物发酵Broussonetia papyrifera叶子提取物 (BLE) 与乳杆菌和Bifidobacterium bifidum增强的生物活性化合物. 发酵BLE显示了皮肤健康和抗氧化剂应用的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 布鲁索内西亚纸 (BP) 叶子以其丰富的生物活性成分而闻名.
- 研究微生物发酵来增强BP叶子提取物 (BLE) 的治疗特性.
研究的目的:
- 选适合发酵BLE的微生物菌株.
- 评估发酵对BLE生物活性化合物含量的影响.
- 评估发酵BLE的生物活性,包括铁酶抑制和抗氧化作用.
主要方法:
- 对微生物菌株的查,确定乳酸菌和Bifidobacterium bifidum是最佳的.
- 在发酵前和之后,总的,黄酸盐,阳和三酸盐的量化.
- 实验室试验用小鼠黑色素瘤B16-F10细胞来评估铁酶抑制,黑色素生产和抗氧化活性.
主要成果:
- 在BLE中,发酵显著增加了总的,黄类,宁和三类.
- 用L. rhamnosus (BLFs) 发酵的BLE抑制了铁酶活性,黑色素的产生和相关的蛋白质表达.
- 用B. bifidum (BBFs) 发酵的BLE显示出显著的抗氧化作用.
结论:
- 微生物发酵增强了Broussonetia papyrifera叶子提取物的生物活性化合物特征.
- 发酵BLE由于其抗氧化特性,在美容应用中显示出有前途的潜力,用于皮肤亮化和医疗应用.
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